Realizing the Vision: Leading Edge Technologies in Biological Systems Workshop to be held in Washington, DC in September or October 2004

国家科学基金会的这笔赠款将为一个基础广泛的科学讲习班提供支助，该讲习班题为：实现远景：生物系统的前沿技术，将于2004年9月或10月在华盛顿举行。 在一次非正式圆桌讨论中确定了讲习班的基本需求，其中包括认识到动物、微生物和植物基因组测序的速度很快，无法与单个基因和/或蛋白质功能的发现速度相匹配。 此外，基因组测序没有解决同样与生物多样性有关的代谢和生理网络问题。 该研讨会旨在关注前沿和新兴技术，这些技术可以使代谢生物化学领域能够在可预见的未来解决日益重要的系统生物学问题。 讲习班的对象是基础广泛的听众，他们综合了研究生物系统的各种科学学科。 它将接待18-20名各自领域的科学领导人（例如，生物信息学和生物系统图;分子门控;代谢通量分析（包括单细胞分析）;生命（代谢）网络;复杂天然产物多样性的分子基础;蛋白质组学和蛋白质结构/功能;以及结构生物学和代谢工程的未来作用。 具体目标包括：（1）提供一个论坛，供主要科学家和其他有关方面就前沿问题进行非正式、深入的对话;（2）通过有关科学学科的代表和有关公众的直接参与，扩大有关讨论和建议的信息的外联和传播; 3）提供一份报告，总结未来的需求，方向和建议，强调新兴前沿概念的重要性及其对理解生命（代谢）网络的潜在影响。更广泛的影响：研讨会将为主要科学家和各种与会者之间的非正式对话提供一个论坛。 研讨会的成果将是一份附有建议的最终书面报告，以帮助了解代谢网络和系统生物学的战略路线图。 该报告（及建议）将在《植物化学》杂志的特刊上发表，并将链接到一个会议网站以及一些专业协会的网站。 组织者还将编写一份适合向公众分发的非技术报告。

This NSF grant will provide support for a broadly based scientific workshop entitled: Realizing the Vision: Leading Edge Technologies in Biological Systems, and will be held in Washington, DC, during September or October of 2004. The underlying need for the workshop was identified during an informal roundtable discussion that included recognition that the rate of sequencing of animal, microbial, and plant genomes was rapid and not being matched by rates of discovery of individual gene and/or protein function. In addition, genomic sequencing does not address the metabolic and physiological network questions also related to biodiversity. The workshop is designed to focus on leading edge and emerging technologies that can bring the field of metabolic biochemistry the capability of addressing systems biology questions of increasing significance in the foreseeable future. The workshop is targeted to a broad-based audience integrating various scientific disciplines that study biological systems. It will host 18-20 scientific leaders in their respective fields (e.g., animal, microbial, and plant science) to lead workshop participants in discussions of topics such as: bioinformatics; biological systems maps; molecular gating; metabolic flux analysis (including single cell analysis); living (metabolic) networks; the molecular basis of complex natural product diversity; proteomics and protein structure/function; and the future roles of structural biology and metabolic engineering. Specific goals include to: 1) provide a forum for informal, incisive dialogue between leading scientists and other interested parties relating to leading edge issues; 2) increase outreach and dissemination of information regarding discussions and recommendations by direct involvement of representatives from related scientific disciplines as well as interested members of the public; 3) provide a report summarizing future needs, directions, and recommendations emphasizing the importance of the emergent leading edge concepts and their potential impact on the understanding of living (metabolic) networks. Broader Impact: The workshop will provide a forum for informal dialogue between leading scientists and a diverse group of participants. The product of the workshop will be a final written report with recommendations, to help inform a strategic roadmap for understanding metabolic networks and systems biology. The report (with recommendations) will be published in a special edition of the journal Phytochemistry, and will be linked to a conference website as well as to websites of a number of professional societies. Organizers will also produce a non-technical report suitable for dissemination to the general public.