ACT/SGER: Technology for Field Portable Biosensors

ACT/SGER：现场便携式生物传感器技术

• 批准号: 0442047
• 负责人: Christopher Bowman
• 金额: --
• 依托单位: University of Colorado at Boulder
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0442047&HistoricalAwards=false
• 关键词: ACT; SGER; Technology; Field; Portable

This project will develop radical polymerization-based techniques for amplification of biomolecular recognition events, specifically olignucleotide hybridization, such that detection of these events will be more facile, highly parallel, feasible at reduced event threshold concentrations, and detectable with an inexpensive detector. Radical polymerizations afford a unique opportunity to amplify biomolecular recognition events since each initiation event leads to the polymerization of a large number of vinyl groups. When initiation is, in space or time, coupled to the oligonucleotide recognition event, polymerization of highly absorptive moieties provide means for amplification and subsequent detection by absorption, enabling the design of a simple, portable detector. This award is supported jointly by the NSF and the Intelligence Community. The Approaches to Combat Terrorism Program in the Directorate for Mathematics and Physical Sciences supports new concepts in basic research and workforce development with the potential to contribute to national security.

该项目将开发基于自由基聚合的技术，用于扩增生物分子识别事件，特别是寡核苷酸杂交，使得这些事件的检测将更容易，高度平行，在降低的事件阈值浓度下可行，并且可以用廉价的检测器检测。自由基聚合提供了放大生物分子识别事件的独特机会，因为每个引发事件导致大量乙烯基的聚合。 当引发在空间或时间上与寡核苷酸识别事件偶联时，高吸收性部分的聚合提供了用于扩增和随后通过吸收进行检测的手段，使得能够设计简单便携的检测器。该奖项由NSF和情报界共同支持。数学和物理科学局的打击恐怖主义办法方案支持基础研究和劳动力发展方面的新概念，这些概念有可能促进国家安全。