SGER: Functional Nonlinear Optical Endoscopy - The Third-Generation Optical Endoscopy Technology Toward Early Cancer Detection At A Cellular Level

SGER：功能性非线性光学内窥镜 - 用于细胞水平早期癌症检测的第三代光学内窥镜技术

• 批准号: 0818473
• 负责人: Huikai Xie
• 金额: --
• 依托单位: University of Florida
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0818473&HistoricalAwards=false
• 关键词: SGER; Functional; Nonlinear; Optical; Endoscopy

0818473XieOver half million Americans are expected to die of cancer this year. This high mortality is mainly due to the lack of detecting cancers at their early stages. For example, early-stage gastric cancer (GC) has a 5-year survival of ~90% whereas the 5-year survival rate of late-stage GC isless than 20%. In collaboration with the International Collaborator (Dr. M. Gu) of this proposal, Dr. Xie demonstrated, for the first time, the principle of a compact NLO microscope based on a doublecladding PCF and a microelectromechanical system (MEMS) mirror [9]. With this novel device, they have demonstrated the world's first 3D 2PF and SHG images of gastric tissue with a penetration depth of ~100 im. In this project, they will use double-clad photonic crystal fibers (PCF) to maximize the coupling efficiency and MEMS technology to miniaturize the imaging probe. The MEMS technology includes lateral-scanning micromirrors and axial-scanning microlenses. Three tasks will be pursued: (1) development of fast-scanning, large-range micromirrors and microlenses; (2) instrumentation development including optomechanical design, electronics design, and miniature probe design and assembling; and (3) imaging experiments and image reconstruction and processing.This SGER project if successful will form a revolutionary foundation for non-invasive early cancer detection at a cellular level.

谢预计今年将有50多万美国人死于癌症。这种高死亡率主要是由于缺乏早期癌症检测。例如，早期胃癌（GC）的5年生存率约为90%，而晚期胃癌的5年生存率不到20%。与国际合作者（M。Gu）的建议，谢博士首次展示了基于双包层PCF和微机电系统（MEMS）反射镜的紧凑型NLO显微镜的原理[9]。利用这种新型设备，他们展示了世界上第一个穿透深度约为100 μ m的胃组织3D 2 PF和SHG图像。在这个项目中，他们将使用双包层光子晶体光纤（PCF）来最大限度地提高耦合效率，并使用MEMS技术来实现成像探头的小型化。MEMS技术包括横向扫描微镜和轴向扫描微透镜。将执行三项任务：该项目的主要目标是：（1）快速扫描、大范围微镜和微透镜的开发;（2）仪器开发，包括光机设计、电子设计和微型探针的设计和组装;（3）成像实验和图像重建与处理。该SGER项目如果成功，将为细胞水平的非侵入性早期癌症检测奠定革命性的基础。