Acquisition of an Electron Paramagnetic Resonance Spectrometer for Nanoscience and Biotechnology Research and Education

购买电子顺磁共振波谱仪用于纳米科学和生物技术研究和教育

• 批准号: 0443616
• 负责人: Graham Jones
• 金额: $ 13.19万
• 依托单位: Northeastern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0443616&HistoricalAwards=false
• 关键词: Acquisition; Electron; Paramagnetic; Resonance; Spectrometer

With support from the Chemistry Research Instrumentation and Facilities -Multiuser Instrument Acquisition (CRIF-MU) Program, the Department of Chemistry at Northeastern University will acquire an Electron Paramagnetic Resonance (EPR) Spectrometer. Faculty will use this instrument to carry out research in several areas as follows: a) electrostatic mapping of proteins by high field EPR spin labeling; b) mechanism of AP endonuclease interaction with abasic DNA; c) structural changes in the estrogen receptor with drug binding; d) dynamics of drug interactions with bulge-forming DNA; e) characterization of novel materials for spintronic devices; f) measurements of interfacial interactions in nanocomposite fuel cell and catalytic membranes; g) characterization of conducting polymers synthesized by green chemistry; and h) EPR of novel magnetic materials. An electron paramagnetic resonance (EPR) spectrometer yields information on the molecular and electronic structure of molecules. It may also be used to obtain information about the lifetimes of free radicals, short-lived species that are often essential for the initiation of tumor growth and/or a variety of chemical reactions. These studies will have an impact in a number of areas, from nanoscience to materials chemistry and biotechnology.

在化学研究仪器和设施-多用户仪器获取（CRIF-MU）计划的支持下，东北大学化学系将获得一台电子顺磁共振（EPR）光谱仪。教师将使用该仪器开展以下几个领域的研究：a）通过高场EPR自旋标记对蛋白质进行静电绘图; B）AP核酸内切酶与无碱基DNA相互作用的机制; c）药物结合引起的雌激素受体的结构变化; d）药物与形成凸起的DNA相互作用的动力学; e）自旋电子器件新型材料的表征; f）纳米复合燃料电池和催化膜中界面相互作用的测量; g）通过绿色化学合成的导电聚合物的表征;和h）新型磁性材料的EPR。 电子顺磁共振（EPR）光谱仪产生分子和分子电子结构的信息。它还可以用于获得有关自由基寿命的信息，自由基是通常对肿瘤生长和/或各种化学反应的起始至关重要的短寿命物质。这些研究将在许多领域产生影响，从纳米科学到材料化学和生物技术。