Conference: 2005 3-D Electron Microscopy of Macromolecules Gordon Conference to be Held June 12-17, 2005 in New England

会议：2005年大分子3D电子显微镜戈登会议将于2005年6月12日至17日在新英格兰举行

• 批准号: 0443981
• 负责人: Kenneth Downing
• 金额: $ 0.5万
• 依托单位: Gordon Research Conferences
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0443981&HistoricalAwards=false
• 关键词: Conference; 2005; Electron; Microscopy; Macromolecules

This grant will partially support the 11th Gordon Research Conference on 3D Electron Microscopy of Macromolecules. Electron microscopy (EM) occupies a unique position in the biological armamentarium in that it can address questions at the molecular and cellular level that are unapproachable by other structural methods. EM can bridge light microscopic studies at subcellular resolutions with atomic resolution structures provided by X-ray crystallography and NMR. Recent, technical breakthroughs enable 3D structures to be determined with ever increasing accuracy thereby opening the way to the study of macromolecular systems under defined physiological conditions. The result is new opportunities for understanding biological mechanisms, interactions between macromolecules and the principles of biomolecular design.The 2005 Conference is organized around the theme of "Whither EM?" - looking forward to envision how to move from mainly gathering structural information to improving understanding of biological mechanisms and function. The goal is to create a dynamic forum for (i) the dissemination of major progress in the field over the past two years and (ii) identification of new technical and biological challenges which must be addressed in order for 3D EM to become an essential and ubiquitous tool for solving cell biological problems. In the spirit of the Gordon Conference, a program has been chosen that represents the frontier of the field. Speakers have been chosen based on the importance of their recent contributions and the potential impact of their particular research approach. Speakers from outside the field have been selected in the hope of fostering interdisciplinary approaches and for challenging the field to reach in directions it has so far not contemplated. Based on past experience, it is confidently expected that the 3D EM Gordon Conference will continue to play a central role in defining new technical challenges, and in focusing a concerted approach to understanding fundamental biological questions. The impact of the conference will be the improved abilities of the participants and their colleagues to carry out their current projects on subjects of importance in basic biology and medicine, and the inspiration to develop new directions that take advantage of new knowledge and capabilites in advancing these fields. Intellectual Merit: This series of conferences fosters an integrated view of biological complexity by bringing together scientists working at different levels of the structural hierarchy. These meetings serve to define the challenges of the future and to focus a concerted approach to problems in the preparation, imaging and interpretation of biological specimens that range in size from the molecular to the subcellular. The impact of the preceding ten conferences has been such that the 3D EM community has come to regard this Gordon Conference as an event of pivotal importance. Thus the intellectual merit of the activity lies in the sharing of information on latest results and technological developments among participants. There are very few opportunities for organized training in this type of work. The 3DEM GRC is the largest gathering of people at the cutting edge of molecular and three-dimensional microscopy in terms of the number of attendees and the length of the conference. Broader Impact: The broader impact of the 3DEM GRC is far reaching, as attendees return to their labs with new insights on how EM can be better used to address a wide range of problems in molecular and subcellular structure. The Conference provides one of the primary venues for introducing modern biological electron microsocpy to new users and disseminating the very latest advances to the community. It is thus unique in the amount of information shared, the training it provides to those new to the field, and the intellectual support it provides to even the most established labs. It is also a forum for presenting and discussing the insights and implications derived from the basic technology that it helps to foster.

这笔赠款将部分支持第11届戈登研究会议的大分子三维电子显微镜。 电子显微镜（EM）在生物仪器中占有独特的地位，因为它可以解决其他结构方法无法解决的分子和细胞水平的问题。 EM可以在亚细胞分辨率的光学显微镜研究与X射线晶体学和NMR提供的原子分辨率结构之间架起桥梁。 最近的技术突破使3D结构能够以越来越高的精度确定，从而为在限定的生理条件下研究大分子系统开辟了道路。 其结果是新的机会，了解生物机制，大分子之间的相互作用和生物分子设计的原则。“--期待着设想如何从主要收集结构信息转向提高对生物机制和功能的理解。 我们的目标是创建一个动态的论坛，（i）传播过去两年在该领域的重大进展，（ii）确定新的技术和生物学挑战，必须解决，以使3D EM成为解决细胞生物学问题的重要和普遍存在的工具。 本着戈登会议的精神，选择了一个代表该领域前沿的计划。 发言者的选择是基于他们最近的贡献和他们的特定研究方法的潜在影响的重要性。 从外地挑选了发言者，希望促进跨学科的方法，并向外地提出挑战，以达到它迄今尚未考虑的方向。 根据过去的经验，我们相信3D EM Gordon会议将继续在确定新的技术挑战方面发挥核心作用，并集中精力采取协调一致的方法来理解基本的生物学问题。 会议的影响将是提高参与者及其同事在基础生物学和医学重要课题上开展现有项目的能力，并启发他们开发利用新知识和能力推进这些领域的新方向。智力优势：这一系列会议通过汇集在结构层次不同层次工作的科学家，促进了对生物复杂性的综合看法。这些会议有助于确定未来的挑战，并集中协调一致的方法来解决从分子到亚细胞大小不等的生物标本的制备、成像和解释方面的问题。前十次会议的影响已经使得3D EM社区已经将这次戈登会议视为具有关键重要性的事件。 因此，活动的智力价值在于参与者之间分享有关最新成果和技术发展的信息。 在这类工作中，很少有机会接受有组织的培训。 3DEM GRC是分子和三维显微镜前沿最大的聚会，就与会者人数和会议长度而言。 更广泛的影响：3DEM GRC的广泛影响是深远的，因为与会者返回他们的实验室，对如何更好地利用EM来解决分子和亚细胞结构中的广泛问题有了新的见解。 该会议提供了向新用户介绍现代生物电子显微镜和向社区传播最新进展的主要场所之一。 因此，它在共享的信息量，为新领域提供的培训以及为最成熟的实验室提供的智力支持方面是独一无二的。 它也是一个论坛，介绍和讨论从它帮助促进的基本技术中得出的见解和影响。