The effect of adipocytokines on osteoimmunological processes

脂肪细胞因子对骨免疫过程的影响

基本信息

项目摘要

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by progressive joint destruction. Adipocytes influence the inflammatory processes active in RA by secreting adipocytokines, which are also produced locally by synovial cells. Adipocytokines such as adiponectin and visfatin/PBEF stimulate the production of matrix-degrading enzymes and pro-inflammatory cytokines by RA synovial fibroblasts. Adiponectin suppresses osteoclasts and activates osteoblasts in mice, inhibits TLR4 ligand-induced osteoclastogenesis in vitro and inhibits TNF/RANKL-induced osteoclast differentiation. In contrast, adiponectin induces RANKL in osteoblasts while inhibiting OPG. The aim of the study is to identify and target adipocytokines or adipocytokine isoforms leading to bone remodelling. Therefore, the distribution of adipocytokines, their isoforms, receptors and adipokine expressing cell types at sites of bone resorption will be examined. Analysis of the effects of adipocytokines and their isoforms on osteoclasts will focus on factors of inflammation and bone resorption in RA. Unknown adipokine-mediated pathways and inflammatory processes influencing bone resorption and the inhibition of the adipokine-mediated mechanisms will be elucidated and investigated in vitro as well as translational in established animal models of RA.
风湿性关节炎(RA)是一种以进行性关节破坏为特征的慢性炎症性疾病。脂肪细胞通过分泌脂肪细胞因子影响RA中活跃的炎症过程,脂肪细胞因子也由滑膜细胞局部产生。脂联素和内脂素/PBEF等脂肪细胞因子刺激RA滑膜成纤维细胞产生基质降解酶和促炎细胞因子。脂联素在小鼠中抑制破骨细胞并活化成骨细胞,在体外抑制TLR 4配体诱导的破骨细胞生成并抑制TNF/RANKL诱导的破骨细胞分化。相反,脂联素在成骨细胞中诱导RANKL,同时抑制OPG。该研究的目的是鉴定和靶向导致骨重建的脂肪细胞因子或脂肪细胞因子亚型。因此,将检查脂肪细胞因子、其亚型、受体和脂肪细胞因子表达细胞类型在骨吸收部位的分布。分析脂肪细胞因子及其亚型对破骨细胞的影响将集中在RA的炎症和骨吸收因素上。未知的脂肪因子介导的途径和炎症过程影响骨吸收和抑制脂肪因子介导的机制将阐明和研究在体外以及翻译在建立的动物模型的RA。

项目成果

期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Expression of adipocytokines at sites of bone remodelling in rheumatoid arthritis
类风湿性关节炎骨重建部位脂肪细胞因子的表达
  • DOI:
    10.1136/annrheumdis-2011-201237.21
  • 发表时间:
    2012
  • 期刊:
  • 影响因子:
    27.4
  • 作者:
    Krumbholz G;Lehr A;Rickert M;Rehart S;Schett G;Müller-Ladner U;Neumann E
  • 通讯作者:
    Neumann E
FRI0039 VISFATIN/PBEF in bone remodelling of rheumatoid arthritis
FRI0039âVISFATIN/PBEF 在类风湿性关节炎骨重建中的作用
  • DOI:
    10.1136/annrheumdis-2012-eular.2496
  • 发表时间:
    2012
  • 期刊:
  • 影响因子:
    27.4
  • 作者:
    Krumbholz G;Junker S;Lehr A;Rickert M;Schett G;Rehart M;Müller-Ladner U;Neumann E
  • 通讯作者:
    Neumann E
Deletion of the receptor tyrosine kinase Tyro3 inhibits synovial hyperplasia and bone damage in arthritis
  • DOI:
    10.1136/annrheumdis-2012-202907
  • 发表时间:
    2014-04-01
  • 期刊:
  • 影响因子:
    27.4
  • 作者:
    Ruiz-Heiland, Gisela;Zhao, Yi;Schett, Georg
  • 通讯作者:
    Schett, Georg
A8.18 Visfatin/PBEF in Bone Remodelling of Rheumatoid Arthritis
A8 18âVisfatin/PBEF 在类风湿性关节炎骨重塑中的作用
  • DOI:
    10.1136/annrheumdis-2013-203222.18
  • 发表时间:
    2013
  • 期刊:
  • 影响因子:
    27.4
  • 作者:
    Krumbholz G;Junker S;Lehr A;Rickert M;Schett G;Lange U;Rehart S;Müller-Ladner U;Neumann E.
  • 通讯作者:
    Neumann E.
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Privatdozentin Dr. Elena Neumann其他文献

Privatdozentin Dr. Elena Neumann的其他文献

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{{ truncateString('Privatdozentin Dr. Elena Neumann', 18)}}的其他基金

Adiponektin und Resistin Isoformen in der Pathophysiologie der rheumatoiden Arthritis
脂联素和抵抗素亚型在类风湿性关节炎病理生理学中的作用
  • 批准号:
    202499126
  • 财政年份:
    2011
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Adipozytokine in der Pathophysiologie der rheumatoiden Arthritis
脂肪细胞因子在类风湿性关节炎病理生理学中的作用
  • 批准号:
    32929809
  • 财政年份:
    2007
  • 资助金额:
    --
  • 项目类别:
    Research Grants

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Evaluation of association between adipocytokines and childhood obesity and asthma: birth cohort study
脂肪细胞因子与儿童肥胖和哮喘之间关联的评估:出生队列研究
  • 批准号:
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Effects of phototherapy on TH 17 cells and adipocytokines in patients with psoriasis
光疗对银屑病患者TH 17细胞及脂肪细胞因子的影响
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Obesity and Breast Cancer: Relevance of dysfunctional mammary adipose tissue
肥胖与乳腺癌:乳腺脂肪组织功能障碍的相关性
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    367816
  • 财政年份:
    2016
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Regulation of pathological vascular remodeling by a novel adipocytokines
新型脂肪细胞因子对病理性血管重塑的调节
  • 批准号:
    16K09512
  • 财政年份:
    2016
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    --
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Trabecular bone microstructure in the mandibular residual ridge of elderly women, and its relationship to their bone metabolic markers, adipocytokines, and calcaneus BMD
老年女性下颌残嵴骨小梁微结构及其与骨代谢标志物、脂肪细胞因子、跟骨骨密度的关系
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  • 财政年份:
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The analysis of mechanism of the prevention against stroke recurrence via apoptosis and adipocytokines by therapeutic exercise
治疗运动通过细胞凋亡和脂肪细胞因子预防脑卒中复发的机制分析
  • 批准号:
    26350582
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    2014
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Establishment of Effective Nutrition Guidance Based on the Nutrients and Adipocytokines to Prevent Cardiovascular Diseases
建立基于营养素和脂肪细胞因子的有效营养指导预防心血管疾病
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Adipocytokines and follicular development
脂肪细胞因子和卵泡发育
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    24791681
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    2012
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Mechanism analysis of colorectal ACF and functional analysis of adipocytokines
结直肠ACF机制分析及脂肪细胞因子功能分析
  • 批准号:
    24590948
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Evaluation of autonomic nervous system function, body fat distribution and metabolic profile in children with PWS.
PWS 儿童自主神经系统功能、体脂肪分布和代谢特征的评估。
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