ABA Signaling Networks Controlling the Transition from Embryogenesis to Seedling Growth
ABA 信号网络控制从胚胎发生到幼苗生长的转变
基本信息
- 批准号:0446048
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing grant
- 财政年份:2005
- 资助国家:美国
- 起止时间:2005-03-01 至 2011-02-28
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Production of healthy nutrient-rich seeds that delay their germination until field conditions are optimal for survival is controlled by integration of information from internal and environmental signals. One of the major internal regulators of both seed maturation and germination is the hormone abscisic acid (ABA). Genetic studies have identified genes that are required for normal seed maturation and ABA sensitivity of germination and seedling growth. Many of these genes encode transcription factors, i.e. proteins that bind to DNA and regulate expression of many other genes. Two of these factors, ABI4 and ABI5, each appear to regulate less than 10% of all ABA-regulated genes but confer hypersensitivity to ABA and other stresses when overproduced, suggesting that the relatively small group of genes they regulate are a core component of response to these signals. Comparison of ABA-induced genes in lines that either lack or overproduce these factors identified 16 potential regulatory loci that appear to be directly regulated by ABI4 or ABI5, in addition to many genes thought to mediate stress tolerance and a large number of genes of unknown function. The experiments outlined in this proposal will use genetic and molecular studies to determine which of these newly identified regulators are important for seed maturation and specific stress responses. One intriguing possibility suggested by the preliminary results is that ABA signaling via these ABI loci may enhance responses to other signals by increasing expression of appropriate receptors. Broader impacts of these studies include training of postdocs, and graduate and undergraduate students. Finally, these results may lead to strategies for manipulation of seed nutritional, germination or storage qualities to prevent millions of dollars in crop losses.
通过整合来自内部和环境信号的信息来控制健康的营养丰富的种子的生产,这些种子延迟发芽,直到田间条件最适合生存。激素脱落酸(阿坝)是种子成熟和萌发的主要内部调节剂之一。遗传研究已经确定了正常种子成熟和发芽和幼苗生长的阿坝敏感性所需的基因。这些基因中的许多编码转录因子,即与DNA结合并调节许多其他基因表达的蛋白质。这些因素中的两个,ABI4和ABI5,每个似乎调节不到10%的所有ABA调节基因,但赋予超敏反应阿坝和其他压力时,过度生产,这表明,相对较小的一组基因,他们调节这些信号的核心组成部分。比较ABA诱导的基因,无论是缺乏或过量生产这些因素的线,确定了16个潜在的调控位点,似乎是直接调节ABI4或ABI5,除了许多基因被认为是介导的胁迫耐受性和大量的基因未知的功能。本提案中概述的实验将使用遗传和分子研究来确定这些新鉴定的调节剂中哪些对种子成熟和特定胁迫反应是重要的。一个有趣的可能性建议的初步结果是,阿坝信号通过这些ABI基因座可能会增强响应其他信号通过增加适当的受体的表达。这些研究的更广泛影响包括对博士后、研究生和本科生的培训。最后,这些结果可能会导致种子营养,发芽或储存质量的操纵策略,以防止数百万美元的作物损失。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Ruth Finkelstein其他文献
Evaluation of a new contraceptive cream-jel based on long-term usage
- DOI:
10.1016/0002-9378(59)90542-3 - 发表时间:
1959-09-01 - 期刊:
- 影响因子:
- 作者:
Ruth Finkelstein;Raymond B. Goldberg - 通讯作者:
Raymond B. Goldberg
The cost of HIV medication adherence support interventions: Results of a cross-site evaluation
HIV 药物依从性支持干预措施的成本:跨站点评估的结果
- DOI:
10.1080/09540120500100635 - 发表时间:
2005 - 期刊:
- 影响因子:1.7
- 作者:
B. R. Schackman;Ruth Finkelstein;Christopher P. Neukermans;L. Lewis;L. Eldred;Evaluation Team - 通讯作者:
Evaluation Team
A critical study of the efficacy of jelly as a contraceptive
- DOI:
10.1016/0002-9378(52)90085-9 - 发表时间:
1952-03-01 - 期刊:
- 影响因子:
- 作者:
Ruth Finkelstein;Alan Guttmacher;Raymond Goldberg - 通讯作者:
Raymond Goldberg
Millions of medical care dollars for indigents
- DOI:
10.1007/bf01318932 - 发表时间:
1983-09-01 - 期刊:
- 影响因子:2.200
- 作者:
Lillian Emmons;James E. Burnett;Ruth Finkelstein;Bernice Frieder;Gail Long;Dennis Lettenauer;Cynthia Miller - 通讯作者:
Cynthia Miller
Evaluating Community-based Prevention Programs
- DOI:
10.1007/s11524-009-9395-y - 发表时间:
2009-08-07 - 期刊:
- 影响因子:4.100
- 作者:
Ana Cristina Garcia;Jeffrey Levi;Ruth Finkelstein - 通讯作者:
Ruth Finkelstein
Ruth Finkelstein的其他文献
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{{ truncateString('Ruth Finkelstein', 18)}}的其他基金
Modulators of the Abscisic Acid Core Signaling Pathway
脱落酸核心信号通路的调节剂
- 批准号:
1558011 - 财政年份:2016
- 资助金额:
-- - 项目类别:
Continuing Grant
AB15: A bZIP Protein Regulating ABA Response
AB15:调节 ABA 反应的 bZIP 蛋白
- 批准号:
9982779 - 财政年份:2000
- 资助金额:
-- - 项目类别:
Continuing grant
AB14: A Putative Transcription Factor Regulating Arabidopsis Seed ABA Response
AB14:调节拟南芥种子 ABA 反应的假定转录因子
- 批准号:
9728297 - 财政年份:1998
- 资助金额:
-- - 项目类别:
Continuing grant
Molecular Genetic Analysis of the Arabidopsis AB12 Locus
拟南芥 AB12 基因座的分子遗传学分析
- 批准号:
9105241 - 财政年份:1991
- 资助金额:
-- - 项目类别:
Standard Grant
Molecular Analysis of Arabidopsis Genes Involved in Responseto Abscisic Acid
拟南芥对脱落酸反应相关基因的分子分析
- 批准号:
8903425 - 财政年份:1989
- 资助金额:
-- - 项目类别:
Standard Grant
Postdoctoral Research Fellowships in Plant Biology
植物生物学博士后研究奖学金
- 批准号:
8608512 - 财政年份:1986
- 资助金额:
-- - 项目类别:
Fellowship Award
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