Electrostatically Bound Protein-Lipid Bilayer Domains

静电结合的蛋白质-脂质双层结构域

• 批准号: 0452375
• 负责人: James Weisshaar
• 金额: $ 45.5万
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0452375&HistoricalAwards=false
• 关键词: Electrostatically; Bound; Protein; Lipid; Bilayer

In this project, funded by the Experimental Physical Chemistry Program of the Chemistry Division, Prof. James C. Weisshaar of the University of Wisconsin - Madison and his graduate research students will use the methods of physical chemistry to attempt to understand the fundamental mechanisms in a cell's plasma membrane responsible for exocytosis. The primary tool will be single-molecule fluorescence microscopy of mobile protein molecules on a synthetic planar lipid bilayer. The methods developed should be applicable to other interesting biophysical systems.Besides the potential broader impact of the proposed research on other biophysical systems, the young researchers working on this project will be exposed to a unique interdisciplinary experience. In addition, Prof. Weisshaar will incorporate aspects of his research into the undergraduate courses that he teaches, and he will visit local community organizations to promote better understanding of the modern research university.

在本研究计画中，由化学系实验物理化学计画所资助。威斯康星州-麦迪逊大学的Weisshaar和他的研究生将使用物理化学的方法，试图了解细胞质膜中负责胞吐作用的基本机制。 主要的工具将是单分子荧光显微镜的移动的蛋白质分子的合成平面脂双层。 所开发的方法应适用于其他有趣的生物物理系统。除了拟议的研究对其他生物物理系统的潜在更广泛的影响外，参与该项目的年轻研究人员将获得独特的跨学科经验。 此外，Weisshaar教授将把他的研究纳入他所教授的本科课程，他将访问当地社区组织，以促进更好地了解现代研究型大学。