Acquisition of Equipment for Screening Catalytic Reactions at High-Pressure

威斯康星大学化学系的Robert Hamers、Clark R. Landis和shanan S. Stahl将获得化学研究仪器和设施：系内多用户仪器项目（CRIF:MU）授予的这一奖项，用于研究高压（50-3000 psig）下的液相化学反应和催化过程。该设备包括反应器，可通过红外光谱和衰减全反射来监测反应动力学，适用于高压下的反应筛选。该设备将用于研究与空气敏感试剂或厌氧条件下的高压反应，包括催化氢甲酰化，聚合和羰基化反应，以及氧化反应，高温化学和氧化亚氮化学的研究。高压反应在化学和制药工业中具有广泛的意义，包括一些最重要的大规模化学过程：有氧氧化、加氢和烯烃聚合。这种类型的新反应和对现有反应的基本见解对于推进该领域至关重要；然而，由于需要使用确保安全的专门设备，这类研究变得复杂。本提案中所要求的设备将能够在高压下发现和研究各种化学反应的机理。学生将接受培训，在他们的研究和课程作业中正确使用这些设备，为他们在化学和制药行业的工作做好准备

AbstractWith this award from the Chemistry Research Instrumentation and Facilities: Departmental Multi-User Instrumentation program (CRIF:MU), Robert Hamers, Clark R. Landis and Shannan S. Stahl of the University of Wisconsin Department of Chemistry will acquire equipment to study solution-phase chemical reactions and catalytic processes performed at high pressures (50-3000 psig). The equipment includes reactors which allow monitoring reaction kinetics by infrared spectroscopy and attenuated total reflectance suitable for screening of reactions at high pressure. The equipment will be used to investigate at high pressures reactions with air-sensitive reagents or under anaerobic conditions including catalytic hydroformylation, polymerization and carbonylation reactions, and the study of oxidative reactions, high temperature chemistry and nitrous oxide chemistry. High-pressure reactions have widespread significance in the chemical and pharmaceutical industries and include some of the most important large scale chemical processes: aerobic oxidation, hydrogenation and alkene polymerization. New reactions of this type and fundamental insights into existing reactions are critical to advance the field; however, such studies are complicated by the need to use specialized equipment that ensures safety. The equipment requested in this proposal will enable the discovery and mechanistic investigation of a wide range of chemical reactions under high-pressure. Students will be trained in the proper use of this equipment in their research and in course work improving their preparation for jobs in the chemical and pharmaceutical industries