Micro-Instrumentation for Optical Manipulation of Biological Cells with Fine Orientation Control and Low Optical Intensity
用于生物细胞光学操纵的微仪器,具有精细方向控制和低光学强度
基本信息
- 批准号:0454324
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2005
- 资助国家:美国
- 起止时间:2005-09-15 至 2009-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This award is for developing a new instrument, named "opto-plasmonic tweezers," for optical manipulation of biological cells with fine orientation control and low optical-intensity requirement. Non-invasive manipulation of biological cells with light is an important tool for basic biological research. Opto-plasmonic tweezers use polarized light to excite localized surface-plasmon resonance, which consists of a collection of oscillating electrical dipoles, on a metal nanoparticle array. The orientation of these dipoles is parallel to the polarization direction of the light. They generate a patterned-radiation electric field that manipulates the cells through dielectrophoretic interactions, with orientation control dependent on the polarization of the light. Low optical intensity can be achieved due to the high gradient of the radiation field. A micromachined polarization controller will also be fabricated as the first step towards micro-instrumentation. The micro-polarization controller is expected to achieve sub-millisecond response time and therefore can achieve fast rotation control of the biological cells. This is a new instrument for manipulating single biological cells non-invasively using light. Such capability is important in biological research and applications. A chief virtue of the technology is its ability to rotate the cells with high resolution by changing the polarization direction of the light, which cannot be achieved by most of the optical manipulation approaches. Such capability opens the door to building structured biomaterials for potential applications in constructing biofilms and human tissue engineering. This instrument will also be miniaturized using micromachining technology so that it will have a small footprint and low cost. The success of this project will open up new directions for optical manipulations in biological research. This project will also give students valuable experience in doing interdisciplinary research.
这一奖项是因为开发了一种新的仪器,名为“光等离子体镊子”,用于光学操纵具有精细取向控制和低光学强度要求的生物细胞。光对生物细胞的非侵入性操纵是基础生物学研究的重要工具。光等离子体镊子使用偏振光在金属纳米颗粒阵列上激发局部表面等离子体共振,表面等离子体共振由一组振荡的电偶极子组成。这些偶极子的取向与光的偏振方向平行。它们产生一个图案化的辐射电场,通过介电相互作用操纵细胞,方向控制取决于光的偏振。由于辐射场的高梯度,可以获得低的光学强度。微机械偏振控制器也将被制造出来,作为迈向微仪器的第一步。该微偏振控制器有望实现亚毫秒级的响应时间,从而实现对生物细胞的快速旋转控制。这是一种利用光非侵入性操纵单个生物细胞的新仪器。这种能力在生物学研究和应用中非常重要。这项技术的一个主要优点是它能够通过改变光的偏振方向来以高分辨率旋转细胞,这是大多数光学操纵方法无法实现的。这种能力为构建结构化生物材料打开了大门,这些材料在构建生物膜和人体组织工程方面具有潜在应用。该仪器还将使用微机械加工技术进行微型化,从而使其占地面积小、成本低。该项目的成功将为生物研究中的光学操作开辟新的方向。该项目还将为学生提供进行跨学科研究的宝贵经验。
项目成果
期刊论文数量(0)
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Lih Lin其他文献
5.0 Custom Integrated Circuits Academic and Research Staff
5.0 定制集成电路学术和研究人员
- DOI:
- 发表时间:
2009 - 期刊:
- 影响因子:0
- 作者:
B. Musicus;Wyatt;Standley;B. Thompson;H. Wright;Robert;Armstrong;Donald;Baltus;C. Bamji;L. Brocco;Charles E. Hauck;Lih Lin;S. McCormick - 通讯作者:
S. McCormick
Lih Lin的其他文献
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{{ truncateString('Lih Lin', 18)}}的其他基金
BRITE Pivot: Accelerating Manufacturing and Realization of Perovskite Micro-Light Emitting Device (Micro-LED) Displays through Data-driven Learning
BRITE Pivot:通过数据驱动学习加速钙钛矿微发光器件 (Micro-LED) 显示器的制造和实现
- 批准号:
2227285 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Standard Grant
PFI-TT: Enabling Advanced High-Resolution Full-Color Displays with New Color Conversion Technologies
PFI-TT:利用新的色彩转换技术实现先进的高分辨率全彩显示器
- 批准号:
2140788 - 财政年份:2022
- 资助金额:
-- - 项目类别:
Standard Grant
OP: Towards Electrically Pumped Perovskite Quantum Dot Lasers
OP:走向电泵浦钙钛矿量子点激光器
- 批准号:
1807397 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Standard Grant
IDBR: TYPE A: Mass-Sensing Nanostructure-Enhanced Laser Tweezers
IDBR:A 型:质量传感纳米结构增强激光镊子
- 批准号:
1353718 - 财政年份:2014
- 资助金额:
-- - 项目类别:
Standard Grant
Nanoscale quantum dot photodetectors with high integratability for nanophotonic integrated circuits
用于纳米光子集成电路的高集成度纳米级量子点光电探测器
- 批准号:
0925378 - 财政年份:2009
- 资助金额:
-- - 项目类别:
Standard Grant
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