A New Design for Manufacturing Process of Porous Resorbable Implant Materials

本研究的目的是探索从粉末阶段到纤维阶段到多孔支架制造可吸收植入材料的可能性。所设想的制造工艺将特别考虑用于植入材料的额外拉伸强度和韧性的胶原蛋白混合物。该方法是调整造纸工业中的一些关键制造工艺，以更有效和经济地生产生物相容性开细胞多孔植入材料。重要的制造概念包括湿端和干端操作以及额外的陶瓷羟基磷灰石纤维转化过程。在湿端操作中，羟基磷灰石和胶原纤维将与化学添加剂混合并均匀分布到移动的丝垫上。在干端操作中，植入材料片将通过一系列干燥设备运输，并装入不同尺寸的片或卷。这项拟议研究的社会效益包括具有模拟自然的开孔多孔微结构的植入材料的潜在可行的大规模生产。在生产先进的生物相容性植入材料方面，纸张制造技术的分支不仅有利于造纸业本身，而且有利于新兴的生物科学和生物工程工业部门。教育方面的影响包括在理工大学的其他跨学科研究所促进多学科工程教育，这是一个位于纽约大都会地区的研究所，专注于不同宗教和种族背景的学生的教育。

The objective of this research is to explore the possibility of manufacturing resorbable implant material from powder phase via fiber stage to porous scaffold. The envisioned manufacturing process will consider in particular the mixture with collagen for extra tensile strength and toughness of implant materials. The approach is to adapt some of the key manufacturing process in the paper-making industry for a more efficient and economic production of biocompatible open cell porous implant materials. The important manufacturing concepts include both wet and dry end operations as well as an additional ceramic hydroxyapatite fiber convertion process. In the wet end operation, hydroxyapatite and collagen fibers will be mixed with chemical additives and distributed uniformly to a moving wire mat. In the dry end operation, implant material sheets will be transported through a serious of drying apparatus and fit into different sized sheets or rolls.The societal benefits of this proposed research include the potentially feasible mass production of implant materials with open cell porous microstructures mimicking the nature. The branching out of the paper manufacturing techniques in the production of advanced biocompatible implant materials is beneficial not only to the paper industry per se but also to the emerging bioscience and bioengineering industrial sectors. The educational impacts include fostering multi-disciplinary engineering education in the Othmer Interdisciplinary Research Institute in Polytechnic University, an institute in the Metropolitan New York area focusing the education of students with different religious and ethnic backgrounds.