A New Design for Manufacturing Process of Porous Resorbable Implant Materials

本研究的目的是探索可吸收种植材料从粉末相经纤维阶段到多孔支架制备的可能性。设想的制造过程将特别考虑与胶原蛋白的混合物，以获得额外的拉伸强度和植入材料的韧性。该方法是调整造纸业的一些关键制造工艺，以更高效、更经济地生产生物兼容的开放细胞多孔植入材料。重要的制造概念包括湿端和干端操作，以及额外的陶瓷羟基磷灰石纤维转化工艺。在湿端作业中，将羟基磷灰石和胶原纤维与化学添加剂混合，均匀分布在移动的金属丝垫上。在干端操作中，种植材料片材将通过一系列干燥设备被输送，并适合不同尺寸的片材或卷材。这项研究的社会效益包括潜在的可行的大规模生产具有模拟自然的开放细胞多孔微结构的种植材料。在生产先进的生物相容植入材料方面，造纸术的发展不仅有利于造纸业本身，也有利于新兴的生物科学和生物工程工业部门。教育影响包括在理工大学的Othmer跨学科研究所促进多学科的工程教育，这是纽约大都会地区的一个研究所，重点是对不同宗教和种族背景的学生进行教育。

The objective of this research is to explore the possibility of manufacturing resorbable implant material from powder phase via fiber stage to porous scaffold. The envisioned manufacturing process will consider in particular the mixture with collagen for extra tensile strength and toughness of implant materials. The approach is to adapt some of the key manufacturing process in the paper-making industry for a more efficient and economic production of biocompatible open cell porous implant materials. The important manufacturing concepts include both wet and dry end operations as well as an additional ceramic hydroxyapatite fiber convertion process. In the wet end operation, hydroxyapatite and collagen fibers will be mixed with chemical additives and distributed uniformly to a moving wire mat. In the dry end operation, implant material sheets will be transported through a serious of drying apparatus and fit into different sized sheets or rolls.The societal benefits of this proposed research include the potentially feasible mass production of implant materials with open cell porous microstructures mimicking the nature. The branching out of the paper manufacturing techniques in the production of advanced biocompatible implant materials is beneficial not only to the paper industry per se but also to the emerging bioscience and bioengineering industrial sectors. The educational impacts include fostering multi-disciplinary engineering education in the Othmer Interdisciplinary Research Institute in Polytechnic University, an institute in the Metropolitan New York area focusing the education of students with different religious and ethnic backgrounds.