SGER: Multi-Scale and Multi-Physics Modeling of Normal and Sickle Red Blood Cells in Aqueous Environment

这项建议的目标是开发水环境中正常红细胞和镰刀状红细胞的新的多尺度和多物理计算模型。重点将是开发一个通用的多尺度建模平台，该平台结合了生物系统的已知机械、物理和化学效应，可以表示为浸入流体中的可变形固体。具体地说，Navier-Stokes方程将与蛋白质分子动力学相耦合，考虑细胞与细胞之间的黏附和变形能力对浸入固体在水环境中宏观行为的影响。这些结果将被用来更好地了解镰状细胞疾病及其治疗。所开发的模型和方法将有助于激发新一代计算生物力学的研究思路，特别是模拟自然的新合成材料的形成，以及各种微操作技术的进一步发展，如微针、微管、扑克和光镊子。

0406601WangThe objective of this proposal is to develop novel multi-scale and multi-physics based computational models for normal and sickle red blood cells in an aqueous environment. The emphasis will be on developing a general multi-scale modeling platform that incorporates known mechanical, physical, and chemical effects for biosystems that can be represented as deformable solid immersed in fluid. Specifically, Navier-Stokes equations will be coupled with protein molecular dynamics in incorporating the effects of cell-cell adhesion and deformability on macroscopic behaviors of immersed solid in aqueous environment. The results will be used to obtain a better understanding of sickle cell diseases and their treatments. The developed models and methods will assist in motivating a new generation of research ideas for computational biomechanics, in particular the formulation of new synthetic materials mimicing nature and the further development of various micromanipulation techniques such as microneedle, micropipet, poker, and optical tweezer.