SGER: Multi-Scale and Multi-Physics Modeling of Normal and Sickle Red Blood Cells in Aqueous Environment

该提案的目的是开发新的多尺度和基于多物理的计算模型，用于在水性环境中的正常和镰状红细胞。重点将是开发一个通用的多尺度建模平台，该平台结合了已知的机械，物理和化学效应的生物系统，可以表示为可变形的固体浸没在流体中。具体而言，Navier-Stokes方程将与蛋白质分子动力学耦合，以纳入细胞-细胞粘附和变形性对浸没固体在水环境中的宏观行为的影响。研究结果将用于更好地了解镰状细胞病及其治疗。所开发的模型和方法将有助于激发新一代计算生物力学的研究思路，特别是模仿自然的新合成材料的配方，以及各种微操作技术的进一步发展，如微针，微吸管，扑克和光学镊子。

0406601WangThe objective of this proposal is to develop novel multi-scale and multi-physics based computational models for normal and sickle red blood cells in an aqueous environment. The emphasis will be on developing a general multi-scale modeling platform that incorporates known mechanical, physical, and chemical effects for biosystems that can be represented as deformable solid immersed in fluid. Specifically, Navier-Stokes equations will be coupled with protein molecular dynamics in incorporating the effects of cell-cell adhesion and deformability on macroscopic behaviors of immersed solid in aqueous environment. The results will be used to obtain a better understanding of sickle cell diseases and their treatments. The developed models and methods will assist in motivating a new generation of research ideas for computational biomechanics, in particular the formulation of new synthetic materials mimicing nature and the further development of various micromanipulation techniques such as microneedle, micropipet, poker, and optical tweezer.