COLLABORATIVE RESEARCH: The Biotransformation of Hydrophobic and Hydrophilic Pharmaceuticals and Their Metabolites by Nitrifying and Heterotrophic Cultures

合作研究：硝化和异养培养物对疏水性和亲水性药物及其代谢物的生物转化

• 批准号: 0504477
• 负责人: Peter Vikesland
• 金额: --
• 依托单位: Virginia Polytechnic Institute and State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0504477&HistoricalAwards=false
• 关键词: COLLABORATIVE; RESEARCH; Biotransformation; Hydrophobic; Hydrophilic

0504477 Love The prevalence of pharmaceutical chemicals in aquatic environments is increasing, especially as detection techniques improve. It is known that existing wastewater treatment often cannot, and does not remove pharmaceutical chemicals from waste streams. In the proposed project, the PIs will test the degradation of four common pharmaceuticals in bioreactors and relate the degradation to the microorganisms present and the reactor configuration. The PIs hypothesize that ammonia oxidizing bacteria (AOB) and heterotrophs work in concert to degrade pharmaceuticals and that bioreactor configuration plays a role in defining the bioavailability of pharmaceuticals and their transformation byproducts.

0504477爱药物化学品在水生环境中的流行正在增加，特别是随着检测技术的改进。众所周知，现有的废水处理通常不能，也不能从废物流中去除药物化学品。在拟议项目中，PI将测试生物反应器中四种常见药物的降解情况，并将降解与存在的微生物和反应器配置联系起来。PI假设氨氧化细菌（AOB）和异养生物协同工作以降解药物，并且生物反应器配置在定义药物及其转化副产物的生物利用度中起作用。