Novel approach to microfluidic sensing and regulation for active flow control

用于主动流量控制的微流体传感和调节的新方法

• 批准号: 0509723
• 负责人: Zonglu Susan Hua
• 金额: $ 18万
• 依托单位: SUNY at Buffalo
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0509723&HistoricalAwards=false
• 关键词: Novel; approach; microfluidic; sensing; regulation

Abstract0509723 PI: Zonglu Susan Hua, SUNY-BuffaloTitle: Novel approach to microfluidic sensing and regulation for active flow controlThis research is focused on fundamental study aimed at developing a novel electrolytic bubble-based sensing mechanism that would enable accurate and sensitive measurement of fluid flow characteristics within the microfluidic channels. The approach to bubble-based sensing is based on that gas bubbles are electrical insulators and the resistance of a microfluidic channel containing the bubble is a sensitive measure of the bubble size, and hence factors that affect it - pressure, flow rate, etc. The approach would add a new group of flow sensing elements into the functional scheme of the microfluidic lab-chip. Both bubble volume and bubble deflation rate are utilized as the sensing modalities. A family of generic sensors including pressure sensors, flow meters, and a novel flow regulator will be developed. These sensors will be designed, characterized, and calibrated in detail towards optimizing and enhancing their sensitivity and dynamic response. Intellectual merit of the these activities include fundamental understanding of microfluidics, as well as broad applications in fields ranging from engineering, biotechnology, to combinatorial and analytical chemistry. Broader educational and outreach impact involve training of undergraduate, graduate, minority, and women students.

摘要0509723 PI：Zonglu Susan Hua，纽约州立大学布法罗分校标题：用于主动流量控制的微流体传感和调节的新方法这项研究的重点是基础研究，旨在开发一种新型的基于电解气泡的传感机制，该机制将能够准确、灵敏地测量微流体通道内的流体流动特性。基于气泡的传感方法基于以下事实：气泡是电绝缘体，而包含气泡的微流体通道的电阻是对气泡尺寸以及影响气泡大小的因素（压力、流速等）的敏感测量。该方法将在微流体实验室芯片的功能方案中添加一组新的流量传感元件。气泡体积和气泡收缩率都被用作传感方式。将开发一系列通用传感器，包括压力传感器、流量计和新型流量调节器。这些传感器将被详细设计、表征和校准，以优化和增强其灵敏度和动态响应。这些活动的智力价值包括对微流体的基本理解，以及在工程、生物技术、组合和分析化学等领域的广泛应用。更广泛的教育和推广影响包括对本科生、研究生、少数族裔和女学生的培训。