Upgrade of Data Acquisition and Processing Systems for two High Resolution and One ESI Mass Spectrometers

两台高分辨率质谱仪和一台 ESI 质谱仪的数据采集和处理系统升级

• 批准号: 9808549
• 负责人: Emile Schweikert
• 金额: $ 9.15万
• 依托单位: Texas A&M Research Foundation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-15 至 1999-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9808549&HistoricalAwards=false
• 关键词: Upgrade; Data; Acquisition; Processing; Systems

This award from the Chemistry Research Instrumentation and Facilities Program will assist faculty in the Department of Chemistry at Texas A&M University to upgrade the Data Acquisition and Processing Systems for two High Resolution and one ESI Mass Spectrometers. The mass spectrometers will support research projects focused on the generation of synthetic peptides, screening of combinatorial peptide libraries, characterization of synthetic mimics for beta sheet initiation, synthesis of organometallics to mimic enzyme containing metal active sites, selective alkylation of cysteine containing proteins and peptides by alkylphenols, synthesis of complex natural products, characterization of bioremediation proteins, metal-ligand complexation, and genetically engineered synthesis of vitamin B12.Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. The addition of the technique of electrospray extends the range of MS to protein and nucleic acid molecular weights far beyond any other technique. The use of electrospray ionization in combination with high resolution provides the latest technique available in mass spectrometry. It affords the chemist one of the most powerful tools available for the characterization of compounds. The acquisition of this capability in mass spectrometry is essential for the prosecution of frontier research in many fields of chemistry.

该奖项来自化学研究仪器和设施计划，将协助德克萨斯农工大学化学系的教师升级两台高分辨率质谱仪和一台 ESI 质谱仪的数据采集和处理系统。 质谱仪将支持以下研究项目：合成肽的生成、组合肽库的筛选、β片层引发的合成模拟物的表征、有机金属化合物的合成以模拟含有金属活性位点的酶、通过烷基酚对含有半胱氨酸的蛋白质和肽进行选择性烷基化、复杂天然产物的合成、 生物修复蛋白、金属-配体络合以及维生素 B12 的基因工程合成。质谱 (MS) 是一种用于探测密切结构细节并获取大量有机、生物有机和有机金属分子的分子组成的技术。电喷雾技术的加入将 MS 的范围扩展到蛋白质和核酸分子量，远远超过任何其他技术。电喷雾电离与高分辨率的结合使用提供了质谱分析中可用的最新技术。它为化学家提供了用于表征化合物的最强大的工具之一。获得这种质谱分析能力对于许多化学领域的前沿研究的开展至关重要。