Mapping cell wall and surface structures of Gram-positive cocci

绘制革兰氏阳性球菌的细胞壁和表面结构图

• 批准号: DP0988700
• 负责人: Prof Mark Walker
• 金额: $ 11.72万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0988700
• 关键词: Mapping; cell; wall; surface; structures

The synthesis of the Gram-positive cell wall and protein transport are fundamental processes, the improved understanding of which will impact across a range of fields including microbiology, biochemistry and biotechnology, and the application and manipulation of Gram-positive bacteria in agriculture, industry and human health. In the long-term, the analysis of the Gram-positive ExPortal and cell wall will identify proteins that may represent targets for therapeutic intervention. Additionally a precise understanding of the mechanisms of secretion of anchorless proteins will have an important impact in the biotechnology field, as new methodologies for the secretion of recombinant proteins of industrial value is a potential outcome.

革兰氏阳性细胞壁的合成和蛋白质的运输是基本的过程，对这一过程的深入了解将影响到包括微生物学、生物化学和生物技术在内的一系列领域，以及革兰氏阳性细菌在农业、工业和人类健康方面的应用和操作。从长远来看，对革兰氏阳性出口门户和细胞壁的分析将确定可能代表治疗干预目标的蛋白质。此外，对无锚定蛋白分泌机制的准确理解将对生物技术领域产生重要影响，因为具有工业价值的重组蛋白分泌的新方法是潜在的结果。