Role of bacteriophage-encoded streptodornase in invasive disease caused by diverse group A streptococcal M serotypes.

噬菌体编码的链球菌酶在不同 A 组链球菌 M 血清型引起的侵袭性疾病中的作用。

• 批准号: nhmrc : 573401
• 负责人: Prof Mark Walker
• 金额: $ 55.51万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-bacteriophage-encoded-m-serotypes/97255
• 关键词: Role; bacteriophage; encoded; streptodornase; invasive

Streptococcus pyogenes (group A streptococcus, GAS) is estimated to cause ~700 million cases of self-limited throat or skin infection each year worldwide. Invasive GAS disease occurs in approximately 1-1000 cases, with associated mortality of 25%. We have recently discovered that a viral infection can reprogram GAS for invasive disease propensity. We will investigate whether this phenomenon is widespread, in order to understand this process and develop future therapeutics.

据估计，化脓性链球菌（A组链球菌，GAS）每年在全球范围内引起约7亿例自限性咽喉或皮肤感染。侵袭性GAS疾病发生在大约1-1000例病例中，相关死亡率为25%。我们最近发现，病毒感染可以重新编程GAS的侵袭性疾病倾向。我们将调查这种现象是否普遍存在，以了解这一过程并开发未来的治疗方法。