Identification and characterisation of Mycoplasma hyopneumoniae surface-molecules that interact with the host epithelium.

与宿主上皮相互作用的猪肺炎支原体表面分子的鉴定和表征。

• 批准号: LP0455306
• 负责人: Prof Mark Walker
• 金额: $ 34.25万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-09-02 至 2008-09-27
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP0455306
• 关键词: Identification; characterisation; Mycoplasma; hyopneumoniae; surface

Mycoplasma hyponeumoniae causes porcine enzootic pneumonia, a disease that significantly impacts swine production. Current vaccines are unable to prevent colonisation of the respiratory tract and are costly to produce and administer. The expression of microbial adhesins that mediate adherence to the extracellular matrix is considered the initial step in host colonisation for many bacterial pathogens. We propose to identify M. hyopneumoniae cell surface moleculaes that interact with components of the extracellular matrix. Targetting these cell surface molecules will lead to therapeutics that prevent disease and block colonisation, eventually eradicating the host pathogen from pig production facilities.

肺炎支原体引起猪地方性肺炎，这是一种严重影响养猪生产的疾病。目前的疫苗不能预防呼吸道的定殖，并且生产和施用成本高。微生物粘附素介导粘附到细胞外基质的表达被认为是许多细菌病原体宿主定殖的初始步骤。我们建议识别M。与细胞外基质组分相互作用的细胞表面分子。针对这些细胞表面分子将产生预防疾病和阻止定植的治疗方法，最终从猪生产设施中根除宿主病原体。