Evolution of bacterial pathogenesis

细菌发病机制的演变

• 批准号: DP140102881
• 负责人: Prof Mark Walker
• 金额: $ 26.01万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140102881
• 关键词: Evolution; bacterial; pathogenesis

Little is known regarding the specific evolutionary steps involved in the emergence of highly virulent microbial pathogens from benign or mildly virulent populations. The group A streptococcus is exemplary of this vexing problem - a large population reservoir of bacteria exists causing only mild infections and a highly virulent strain emerges causing significant disease and mortality. Utilising an extensive WHO reference collection of group A streptococcus isolates. This project will define the evolutionary events that produced the most significant invasive strain designated M1T1. The M1T1 strain emerged in the mid-1980s, has since disseminated globally, yet the evolutionary sequence of events resulting in this emergence are largely unknown.

关于从良性或轻度毒力种群中出现高毒力微生物病原体所涉及的具体进化步骤，人们知之甚少。A组链球菌就是这个令人头疼的问题的典范--存在着大量的细菌库，只会引起轻微的感染，而出现一种高毒力的菌株，会导致严重的疾病和死亡。利用世界卫生组织广泛收集的A组链球菌分离株参考资料。该项目将定义产生最重要的入侵菌株M1T1的进化事件。M1T1毒株出现于20世纪80年代中期，此后在全球传播，但导致这种出现的事件的进化序列在很大程度上尚不清楚。