Molecular characterisation of antibiotic resistance genes in Salmonella enterica and Escherichia coli recovered from food-producing animals and humans.

抗生素耐药性是一个日益严重的全球问题。抗生素抗性基因位于移动的遗传元件上，这些遗传元件可以在远亲细菌之间水平转移。越来越明显的是，健康人携带作为正常微生物植物群一部分的耐药菌群。本研究计划将探讨肠杆菌科细菌的抗药性基因排列。这些耐药细菌对人类和兽医健康构成威胁，因为它们很容易作为食物链的一部分被摄入，并成为抗生素耐药基因向病原体传播的储存库。

Antibiotic resistance is an accelerating global problem. Antibiotic resistance genes are located on mobile genetic elements which can be horizontally transferred between distantly related bacteria. It is becoming increasingly apparent that healthy humans carry populations of resistant bacteria as part of the normal microbial flora. This project will characterise the antibiotic resistance gene arrangements among populations of bacteria which belong to the Enterobacteriaceae. These resistant bacteria represent a threat to human and veterinary health because they are readily ingested as part of the food chain and represent reservoirs for the spread of antibiotic resistance genes to pathogens.