Reductive Catalysis by Heme Proteins

血红素蛋白的还原催化

• 批准号: 0517080
• 负责人: Patrick Farmer
• 金额: $ 38.6万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0517080&HistoricalAwards=false
• 关键词: Reductive; Catalysis; Heme; Proteins

Professor Patrick Farmer, a faculty member in the Department of Chemistry at the University of California at Irvine, is supported by the Inorganic, Bioinorganic and Organometallic Chemistry Program to develop heme-based catalysis. Protein radical generation and electrocatalytic dehalogenations are two reaction targets, and characterization of nitroxyl (HNO) biological reaction pathways is another component of this project. Hybrid protein models for NOx and SOx reductase enzymes are being developed, too. The role of heme enzymes in multi-electron reductions and oxidations provides a rich area of study for chemists. The mutiple biological functions of NO reflect a surprising molecular choice for signaling purposes, and HNO is a closely allied molecule. The combination of classical coordination chemistry, molecular biology and electrochemical techniques assures breadth in training for both graduate and undergraduate students.

Patrick Farmer教授是加州大学尔湾分校化学系的一名教员，他得到了无机、生物无机和有机金属化学项目的支持，致力于开发基于血红素的催化。蛋白质自由基生成和电催化脱卤是两个反应目标，而硝基（HNO）生物反应途径的表征是该项目的另一个组成部分。NOx和SOx还原酶的杂交蛋白模型也正在开发中。血红素酶在多电子还原和氧化中的作用为化学家提供了丰富的研究领域。NO的多种生物学功能反映了信号目的的惊人分子选择，而HNO是一个密切相关的分子。经典配位化学，分子生物学和电化学技术的结合保证了研究生和本科生培训的广度。