MRI: Acquisition of Bruker EMXplus series EPR Spectrometer

MRI:购买布鲁克 EMXplus 系列 EPR 光谱仪

基本信息

  • 批准号:
    1428729
  • 负责人:
  • 金额:
    $ 24.16万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-08-01 至 2017-07-31
  • 项目状态:
    已结题

项目摘要

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Professor Patrick Farmer from Baylor University and colleagues Caleb Martin, Kevin Pinney, Bryan Shaw and John Wood will acquire an electron paramagentic resonance (EPR) spectrometer. This instrument will allow research in a variety of fields such as those that provide insight on how biologically relevant species behave when they possess unpaired electrons. In general, an EPR spectrometer yields detailed information on the geometric and electronic structure of molecular and solid state materials. It may also be used to obtain information about the lifetimes of free radicals, short-lived, highly reactive species involved in valuable chemical transformations as well as the initiation of pathological tumor growth. These studies will impact a number of areas, from the synthesis of inorganic and organic molecules to the development of new solid state materials to compounds of magnetic and biological interest. Employing examples inspired from ongoing research, this instrument will be an integral part of research and teaching at the undergraduate and graduate levels at Baylor University as well as Austin College, the University of Texas at Tyler and Texas Lutheran University.The award is aimed at enhancing research and education at all levels, especially in areas such as (a) investigating biocoordination chemistry of HNO; (b) studying the mechanism of charge regulation in superoxide dismutase-1 and other metalloproteins; (c) studying the pro-oxidant chemistry of melanins; (d) designing, synthesizing and evaluating bioreductive tumor microenvironment; (e) analyzing radical reactions of trialkylborane water complexes; and (f) studying boron radicals, pyridyl phosphine/phosphine oxide coordination chemistry.
在主要研究仪器计划(MRI)的这一奖项和化学研究仪器计划(CRIF)的支持下,贝勒大学的Patrick Farmer教授及其同事Caleb Martin、Kevin Pinney、Bryan Shaw和John Wood将获得电子顺磁共振(EPR)光谱仪。该仪器将允许在各种领域进行研究,例如那些提供洞察生物相关物种在拥有未配对电子时的行为的研究。一般来说,EPR光谱仪可以提供有关分子和固态材料的几何和电子结构的详细信息。它还可以用来获得有关自由基寿命的信息,自由基是参与有价值的化学转化的短暂、高活性物种,以及启动病理性肿瘤生长的信息。这些研究将影响许多领域,从无机和有机分子的合成到新型固态材料的开发,再到具有磁性和生物意义的化合物。该仪器将作为贝勒大学、奥斯汀学院、得克萨斯大学泰勒分校和得克萨斯路德大学的本科生和研究生研究和教学的一部分。该奖项旨在加强各级的研究和教育,特别是在以下领域:(A)研究HNO的生物配位化学;(B)研究超氧化物歧化酶-1和其他金属蛋白的电荷调节机制;(C)研究黑色素的促氧化化学;(D)设计、合成和评估具有生物降解性的肿瘤微环境;(E)分析三烷基硼水络合物的自由基反应;和(F)研究硼自由基、吡啶膦/氧化膦配位化学。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Characterization of the Initial Intermediate Formed during Photoinduced Oxygenation of the Ruthenium(II) Bis(bipyridyl)flavonolate Complex
  • DOI:
    10.1021/acs.inorgchem.6b00852
  • 发表时间:
    2016-08-01
  • 期刊:
  • 影响因子:
    4.6
  • 作者:
    Han, Xiaozhen;Klausmeyer, Kevin K.;Farmer, Patrick J.
  • 通讯作者:
    Farmer, Patrick J.
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Patrick Farmer其他文献

PSS237 - Analyzing Heme-Protein Reactions with Global Analysis and SVD<sub>1</sub> Skeletal Muscle
  • DOI:
    10.1016/j.freeradbiomed.2013.10.658
  • 发表时间:
    2013-11-01
  • 期刊:
  • 影响因子:
  • 作者:
    Adrian L Zapata;Patrick Farmer;Murugaeson Kumar
  • 通讯作者:
    Murugaeson Kumar
168 - Sulfomics and Nitromics: Characterizations of S- and N-Based Speciation in Reactions of S-nitroso-glutathione (GSNO) with Hydrogen Sulfide (H2S)
  • DOI:
    10.1016/j.freeradbiomed.2015.10.210
  • 发表时间:
    2015-10-01
  • 期刊:
  • 影响因子:
  • 作者:
    Murugaeson Ravi Kumar;Tara Clover;Patrick Farmer
  • 通讯作者:
    Patrick Farmer

Patrick Farmer的其他文献

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{{ truncateString('Patrick Farmer', 18)}}的其他基金

Heme protein catalysis and the biocoordination chemistry of HNO
血红素蛋白催化和 HNO 的生物配位化学
  • 批准号:
    1057942
  • 财政年份:
    2011
  • 资助金额:
    $ 24.16万
  • 项目类别:
    Standard Grant
Reductive Catalysis by Heme Proteins
血红素蛋白的还原催化
  • 批准号:
    0517080
  • 财政年份:
    2005
  • 资助金额:
    $ 24.16万
  • 项目类别:
    Continuing Grant
Modeling the Chemistry of the Nitrite and Sulfite Reductases
亚硝酸盐和亚硫酸盐还原酶的化学建模
  • 批准号:
    0100774
  • 财政年份:
    2001
  • 资助金额:
    $ 24.16万
  • 项目类别:
    Continuing Grant
CAREER: Nitrite and Sulfite Reduction by Myoglobin in Surfactant Films
职业:通过表面活性剂薄膜中的肌红蛋白还原亚硝酸盐和亚硫酸盐
  • 批准号:
    9702332
  • 财政年份:
    1997
  • 资助金额:
    $ 24.16万
  • 项目类别:
    Continuing Grant
Orientational Effects in Metal-based Electron Transfers
金属基电子转移中的取向效应
  • 批准号:
    9629938
  • 财政年份:
    1996
  • 资助金额:
    $ 24.16万
  • 项目类别:
    Standard Grant
NSF-NATO Postdoctoral Fellowships
NSF-北约博士后奖学金
  • 批准号:
    9353706
  • 财政年份:
    1993
  • 资助金额:
    $ 24.16万
  • 项目类别:
    Fellowship Award
Postdoctoral Research Fellowships in Chemistry
化学博士后研究奖学金
  • 批准号:
    9302420
  • 财政年份:
    1993
  • 资助金额:
    $ 24.16万
  • 项目类别:
    Fellowship Award

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