CAREER: Nitrite and Sulfite Reduction by Myoglobin in Surfactant Films

这个职业奖在无机，生物无机和有机 化学计划支持帕特里克J的研究和教育计划。 他是位于欧文的加州大学的法默。 的目标 拟议的研究是了解肌红蛋白的新仿生化学 (Mb)包含在电极上的膜内。 这种Mb膜具有 电催化亚硝酸盐和亚硫酸盐还原酶活性。 通过使用 修饰的肌红蛋白，功能活性结构模型， 还原酶将通过电化学方法进行研究。 宗旨 研究包括确定导致N-N的中间体的性质， 和S-S产物并探测还原态的氧原子转移反应 Fe结合的N-和S-氧化物中间体。 修饰的肌红蛋白薄膜将被用作亚硝酸盐的模型 和亚硫酸盐还原酶。 一门针对学生的本科课程 对健康相关职业感兴趣的人将得到发展， 为研究生设立的项目， 研究、在研究实验室的轮换和研讨会。

This CAREER Award in the Inorganic, Bioinorganic and Organometallic Chemistry Program supports the research and education plans of Patrick J. Farmer at the University of California at Irvine. The goal of the proposed research is to understand new biomimetic chemistry of myoglobin (Mb) contained within a film on an electrode. Such Mb-films have electrocatalytic nitrite and sulfite reductase activity. By using modified myoglobins, functionally active structural models for the reductases will be studied by electrochemical methods. Aims of the research include identifying the nature of intermediates leading to N-N and S-S products and to probe oxygen atom transfer reactions from reduced Fe-bound N- and S-oxide intermediates. Modified myoglobins in thin films will be used as models of nitrite and sulfite reductase enzymes. An undergraduate course aimed at students interested in health-related careers will be developed and a training program for graduate students instituted involving collaborative research, rotations in research laboratories and seminars.