CAREER: Nitrite and Sulfite Reduction by Myoglobin in Surfactant Films

无机、生物无机和有机金属化学项目的CAREER奖支持加州大学欧文分校Patrick J. Farmer的研究和教育计划。提出的研究的目标是了解新的仿生化学的肌红蛋白（Mb）包含在薄膜上的电极。这种mb膜具有电催化亚硝酸盐和亚硫酸盐还原酶活性。利用修饰的肌红蛋白，通过电化学方法研究还原酶的功能活性结构模型。研究的目的包括确定导致N-N和S-S产物的中间体的性质，并探测还原铁结合的N-和s -氧化物中间体的氧原子转移反应。薄膜中修饰的肌红蛋白将被用作亚硝酸盐和亚硫酸盐还原酶的模型。将为对健康相关职业感兴趣的学生开设一门本科课程，并为研究生制定一项培训计划，其中包括合作研究、研究实验室轮岗和研讨会。

This CAREER Award in the Inorganic, Bioinorganic and Organometallic Chemistry Program supports the research and education plans of Patrick J. Farmer at the University of California at Irvine. The goal of the proposed research is to understand new biomimetic chemistry of myoglobin (Mb) contained within a film on an electrode. Such Mb-films have electrocatalytic nitrite and sulfite reductase activity. By using modified myoglobins, functionally active structural models for the reductases will be studied by electrochemical methods. Aims of the research include identifying the nature of intermediates leading to N-N and S-S products and to probe oxygen atom transfer reactions from reduced Fe-bound N- and S-oxide intermediates. Modified myoglobins in thin films will be used as models of nitrite and sulfite reductase enzymes. An undergraduate course aimed at students interested in health-related careers will be developed and a training program for graduate students instituted involving collaborative research, rotations in research laboratories and seminars.