Multisensory Form Processing in Extrastriate Visual Cortex

纹状体视觉皮层的多感官形式处理

• 批准号: 0519410
• 负责人: Charles Schroeder
• 金额: --
• 依托单位: Research Foundation For Mental Hygiene Inc
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2008-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0519410&HistoricalAwards=false
• 关键词: Multisensory; Form; Processing; Extrastriate; Visual

Functional neuroimaging studies in humans have established that many visual cortical areas are recruited during tactile tasks. Additional methodological approaches are necessary to characterize the role of such visual cortical activity during non-visual perception and the underlying neural mechanisms. With National Science Foundation funding, this research embodies a collaboration among Drs. Krishnankutty Sathian, John Foxe, and Charles Schroeder that brings different techniques to bear on the issue of multisensory form processing in extrastriate visual cortex. Functional magnetic resonance imaging (fMRI) in humans is being combined with event-related potential (ERP) studies in humans and neurophysiologic studies in macaque monkeys, using experimental designs common to the three methods. The high spatial resolution of fMRI and the high temporal resolution of ERP studies are mutually complementary and allow specification of the temporal profile of neural activity, as well as precise localization. Monkey studies entail a combination of field potential and action potential analyses that allow both direct comparison to human (ERP/fMRI) data and investigation of the cellular bases of ERP and fMRI effects. Specific Aim I investigates the recruitment of visual cortical activity by tactile form discriminations and Specific Aim II explores multisensory interactions between vision and touch, during tactile form perception. The combination of three complementary experimental approaches being brought to bear on a common set of questions, using a common set of tasks, is unique and promises to provide a much more complete picture of the relevant neural processes than any of the approaches in isolation. This tripartite approach allows the acquisition of convergent evidence on the specific brain mechanisms of multisensory interactions, which are increasingly recognized to be ubiquitous and essential for sensory processing as well as other aspects of cognition. Among its broader impacts, this project exemplifies the value of bringing multiple experimental approaches to bear on a set of issues. The project is anticipated to lead eventually to improvement in assistive technology available to individuals with sensory deprivation of any kind. By establishing a long-term collaboration between the three principal investigators, students and post-doctoral trainees will be able to acquire expertise in more than one of the experimental approaches, interact with more than one mentor, and further, train explicitly in the emerging field of multisensory science, a field with few formal training opportunities.

对人类的功能性神经影像学研究已经证实，触觉任务会招募许多视觉皮层区域。额外的方法是必要的，这样的视觉皮层活动在非视觉感知和潜在的神经机制的特点的作用。在美国国家科学基金会的资助下，这项研究体现了Krishnankutty Sathian博士，John Foxe和Charles Schroeder博士之间的合作，该研究采用了不同的技术来研究纹外视觉皮层中的多感觉形式处理问题。人类的功能性磁共振成像（fMRI）正在与人类的事件相关电位（ERP）研究和猕猴的神经生理学研究相结合，使用三种方法共同的实验设计。功能磁共振成像的高空间分辨率和ERP研究的高时间分辨率是相互补充的，并允许规范的时间分布的神经活动，以及精确的定位。猴子研究需要结合场电位和动作电位分析，既可以直接与人类（ERP/fMRI）数据进行比较，也可以研究ERP和fMRI效应的细胞基础。具体目标我调查招聘视觉皮层活动的触觉形式歧视和具体目标II探讨视觉和触觉之间的多感官相互作用，在触觉形式感知。 三种互补的实验方法结合起来，使用一组共同的任务，对一组共同的问题产生影响，这是独一无二的，并且有望提供比任何孤立的方法更完整的相关神经过程的图片。这种三方的方法允许采集会聚证据的具体大脑机制的多感官的相互作用，这是越来越多地被认为是无处不在的感觉处理以及认知的其他方面是必不可少的。在其更广泛的影响中，该项目证明了将多种实验方法应用于一系列问题的价值。预计该项目最终将导致改善任何形式的感官剥夺者可用的辅助技术。通过在三位主要研究者之间建立长期合作，学生和博士后学员将能够获得不止一种实验方法的专业知识，与不止一位导师互动，并进一步明确培训新兴的多感官科学领域，这是一个很少有正式培训机会的领域。