Direct Observation of Vesicle Dynamics, Collision, and Adhesion

直接观察囊泡动力学、碰撞和粘附

基本信息

项目摘要

CBET - 1704668PI: Schroeder, CharlesThis award will support an experimental and numerical study of the dynamics of vesicles, particles composed of liquid or gas that is surrounded by a membrane, suspended in flow. The vesicles in this project are liquid-filled and are surrounded by a lipid bilayer membrane, which makes them similar to vesicles found in biological systems. They are also similar to synthetic vesicles that are used in a variety of consumer products and foods. The goals of the project are to characterize dynamics of the vesicles in flow, to use the behavior of the vesicles to characterize their mechanical properties, and to study collisions between vesicles and their adhesion. To accomplish these goals, vesicles of known composition will be placed in a microfluidic cell that has multiple fluidic channels arranged to keep the vesicle stationary in the surrounding flow. The deformation of single vesicles and collisions among vesicles will be viewed through a microscope. The results of the project will enable practitioners to design robust and stable vesicles for use in products. The project team will participate in the Illinois iRise program, which works with teachers to develop hands-on experimental labs for K-12 and high school students. The team will also develop hands-on demonstrations for students from underrepresented groups participating in local Boys and Girls Clubs.The dynamics of single vesicles will be studied in precisely controlled steady and oscillatory extensional flow. Parameters that affect vesicle shapes and the transition from stable to unstable shapes will be examined, including flow rate, membrane bending energy, membrane elasticity and viscosity. A phase diagram for vesicle stability and deformation in extensional flow will be constructed. Results from the project will help resolve discrepancies between experiments and simulations regarding the onset of vesicle shape instabilities such as pearling. The oscillatory flow used in this project will expose vesicles to time-dependent strains, which will expose the effect of unsteadiness on shape instabilities. Collisions and adhesion of freely-suspended vesicles will be characterized. Most prior work has focused on the weak interaction limit, wherein the membrane bending energy plays a dominant role and membrane elasticity is not relevant. However, vesicle membranes deform and stretch upon collision, which has been predicted to give rise to enhanced interactions and unexpected aggregation. The experiments in this project will study collision and adhesion under these conditions.
CBET -1704668 PI:施罗德,查尔斯该奖项将支持囊泡,由液体或气体组成的颗粒,被膜包围,悬浮在流动中的动力学的实验和数值研究。 该项目中的囊泡充满液体,并被脂质双层膜包围,这使得它们类似于生物系统中发现的囊泡。 它们也类似于用于各种消费品和食品的合成囊泡。 该项目的目标是表征流动中囊泡的动力学,使用囊泡的行为来表征其机械性能,并研究囊泡之间的碰撞及其粘附。 为了实现这些目标,将已知组成的囊泡放置在微流体池中,该微流体池具有多个流体通道,所述多个流体通道被布置成使囊泡在周围流中保持静止。 通过显微镜观察单个囊泡的变形和囊泡之间的碰撞。 该项目的结果将使从业者能够设计出用于产品的强大而稳定的囊泡。 该项目团队将参与伊利诺伊州iRise计划,该计划与教师合作,为K-12和高中学生开发动手实验室。 该小组还将开发动手示范的学生从代表性不足的团体参加当地的男孩和女孩Clubs.The单囊泡的动力学将在精确控制的稳定和振荡的拉伸流进行研究。 将检查影响囊泡形状和从稳定形状到不稳定形状的转变的参数,包括流速、膜弯曲能、膜弹性和粘度。 在拉伸流动中,将构建囊泡稳定性和变形的相图。 该项目的结果将有助于解决实验和模拟之间的差异,关于囊泡形状不稳定性的发生,如珍珠。在这个项目中使用的振荡流将暴露囊泡的时间依赖性应变,这将暴露形状不稳定性的不稳定性的影响。 自由悬浮囊泡的碰撞和粘附将被表征。 大多数先前的工作集中在弱相互作用的限制,其中膜弯曲能起主导作用,膜弹性是不相关的。然而,囊泡膜在碰撞时变形和拉伸,这已经被预测会引起增强的相互作用和意外的聚集。本项目的实验将研究在这些条件下的碰撞和粘附。

项目成果

期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Double-mode relaxation of highly deformed anisotropic vesicles
高度变形各向异性囊泡的双模式弛豫
  • DOI:
    10.1103/physreve.102.010605
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    2.4
  • 作者:
    Kumar, Dinesh;Richter, Channing M.;Schroeder, Charles M.
  • 通讯作者:
    Schroeder, Charles M.
Orientation control and nonlinear trajectory tracking of colloidal particles using microfluidics
使用微流体的胶体颗粒的方向控制和非线性轨迹跟踪
  • DOI:
    10.1103/physrevfluids.4.114203
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    2.7
  • 作者:
    Kumar, Dinesh;Shenoy, Anish;Li, Songsong;Schroeder, Charles M.
  • 通讯作者:
    Schroeder, Charles M.
Flow Topology During Multiplexed Particle Manipulation Using a Stokes Trap
使用斯托克斯陷阱进行多重粒子操纵期间的流拓扑
  • DOI:
    10.1103/physrevapplied.12.054010
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    4.6
  • 作者:
    Shenoy, Anish;Kumar, Dinesh;Hilgenfeldt, Sascha;Schroeder, Charles M.
  • 通讯作者:
    Schroeder, Charles M.
Automation and flow control for particle manipulation
  • DOI:
    10.1016/j.coche.2020.02.006
  • 发表时间:
    2020-09-01
  • 期刊:
  • 影响因子:
    6.6
  • 作者:
    Kumar, Dinesh;Shenoy, Anish;Schroeder, Charles M.
  • 通讯作者:
    Schroeder, Charles M.
Conformational dynamics and phase behavior of lipid vesicles in a precisely controlled extensional flow
精确控制的拉伸流中脂质囊泡的构象动力学和相行为
  • DOI:
    10.1039/c9sm02048a
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    3.4
  • 作者:
    Kumar, Dinesh;Richter, Channing M.;Schroeder, Charles M.
  • 通讯作者:
    Schroeder, Charles M.
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Charles Schroeder其他文献

STROKE AND MYASTHENIA GRAVIS LEAD TO CRISIS IN THE ELDERLY
  • DOI:
    10.1016/j.chest.2019.08.1207
  • 发表时间:
    2019-10-01
  • 期刊:
  • 影响因子:
  • 作者:
    Nick Meyerkord;Yunna Sinskey;Shashank Varakantam;Sana Khan;Charles Schroeder;Nemer Dabage-Forzoli
  • 通讯作者:
    Nemer Dabage-Forzoli
Dose and location-dependent effects of transcranial magnetic stimulation in nonhuman primates
  • DOI:
    10.1016/j.brs.2023.01.513
  • 发表时间:
    2023-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Nipun Perera;Sina Shirinpour;Ivan Alekseichuk;Miles Wischnewski;Gary Linn;Charles Schroeder;Arnaud Falchier;Alexander Opitz
  • 通讯作者:
    Alexander Opitz
Layer-specific effects of electrical stimulation on local field potentials in the primary visual cortex of monkeys
电刺激对猴初级视觉皮层局部场电位的层特异性效应
  • DOI:
    10.1016/j.brs.2024.12.1091
  • 发表时间:
    2025-01-01
  • 期刊:
  • 影响因子:
    8.400
  • 作者:
    Sangjun Lee;Ivan Alekseichuk;Zhihe Zhao;Charles Schroeder;Arnaud Falchier;Alexander Opitz
  • 通讯作者:
    Alexander Opitz
Engineering Zinc Finger Proteins using Accessory Binding Modules
  • DOI:
    10.1016/j.bpj.2011.11.433
  • 发表时间:
    2012-01-31
  • 期刊:
  • 影响因子:
  • 作者:
    Kathryn Trenshaw;Younghoon Kim;Nathan Yee;Peiyi Wang;Charles Schroeder
  • 通讯作者:
    Charles Schroeder
Intracranial electric field measurements during TES. Identifying determinant factors of the electric field distribution
  • DOI:
    10.1016/j.brs.2017.04.081
  • 发表时间:
    2017-07-01
  • 期刊:
  • 影响因子:
  • 作者:
    Alexander Opitz;Erin Yeagle;Axel Thielscher;Charles Schroeder;Ashesh Mehta;Michael P. Milham
  • 通讯作者:
    Michael P. Milham

Charles Schroeder的其他文献

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{{ truncateString('Charles Schroeder', 18)}}的其他基金

Equipment: MRI: Track 2 Acquisition of an Automated High-Throughput System for Combinatorial Design and Development of Complex Polymer Systems
设备: MRI:轨道 2 获取用于复杂聚合物系统的组合设计和开发的自动化高通量系统
  • 批准号:
    2320276
  • 财政年份:
    2023
  • 资助金额:
    $ 30万
  • 项目类别:
    Standard Grant
Collaborative Research: Dynamics and Stability of Multi-Component Lipid Vesicles in Flow
合作研究:多组分脂质囊泡流动的动力学和稳定性
  • 批准号:
    2147560
  • 财政年份:
    2022
  • 资助金额:
    $ 30万
  • 项目类别:
    Standard Grant
Collaborative Research: Micromechanics of Meniscus-bound Particle Clusters
合作研究:弯月面束缚粒子簇的微观力学
  • 批准号:
    2030537
  • 财政年份:
    2020
  • 资助金额:
    $ 30万
  • 项目类别:
    Standard Grant
Collaborative Research: Dynamics of Circular Macromolecules (DNA): From Single Molecules to Highly Entangled States
合作研究:圆形大分子(DNA)动力学:从单分子到高度纠缠态
  • 批准号:
    1604038
  • 财政年份:
    2016
  • 资助金额:
    $ 30万
  • 项目类别:
    Standard Grant
WORKSHOP: Neurobiology of Cognition: Circuits, dynamics, action and perception GRC & GRS
研讨会:认知神经生物学:回路、动力学、动作和感知 GRC
  • 批准号:
    1441810
  • 财政年份:
    2014
  • 资助金额:
    $ 30万
  • 项目类别:
    Standard Grant
CAREER: Molecular Rheology of Architecturally Complex Polymers
职业:结构复杂聚合物的分子流变学
  • 批准号:
    1254340
  • 财政年份:
    2013
  • 资助金额:
    $ 30万
  • 项目类别:
    Standard Grant
Multisensory Form Processing in Extrastriate Visual Cortex
纹状体视觉皮层的多感官形式处理
  • 批准号:
    0519410
  • 财政年份:
    2005
  • 资助金额:
    $ 30万
  • 项目类别:
    Continuing Grant

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