Acquisition Of A Fluorescence-Activated Cell Sorter To Support Research And Research Training at Chicago State University, A Minority Serving, Undergraduate Institution

采购荧光激活细胞分选仪以支持芝加哥州立大学（少数族裔本科院校）的研究和研究培训

• 批准号: 0520869
• 负责人: Walid Al-Ghoul
• 金额: $ 40.8万
• 依托单位: Chicago State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-15 至 2008-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0520869&HistoricalAwards=false
• 关键词: Acquisition; Fluorescence; Activated; Cell; Sorter

This award is for the acquisition of a fluorescence-activated cell sorter (FACS) that will support research, teaching, curriculum improvement, and professional development in the Department of Biological Sciences at Chicago State University. The FACS system allows the users to identify and sort subpopulations of cells based on natural or experimentally introduced parameters that include cell-surface molecules, genetic content, and general cell shape and size. The cell types to be examined by the PI and the three co-PIs range from mammalian gut mucosa and immune cells (Drs Al-Ghoul and Swier) to protozoa (Dr Maselli) and plant protoplasts (Dr Poturi). The goals of the projects proposed for this award relate to basic cellular mechanisms associated with the intestinal mucosa barrier, host-pathogen interactions, cell vesicle traffic, and environmental conservation and crop improvement. Dissemination of the knowledge and use of the FACS by these faculty and their students will assure that the acquisition of a FACS will have a major impact on the research exploration and training environment at Chicago State University, bringing it to a level that is more compatible with current standards in research and training.In addition to its tremendous impact on the scientific research environment at Chicago State University, the acquisition of the FACS system is a significant addition to the infrastructure needed for teaching, curriculum improvement, and professional development. At the basic level, it is expected to play a central role in expanding inquiry-based learning, fostering student collaborations, and providing valuable hands-on experience with advanced technology. This is certain to advance the level and quality of instruction in courses taught or designed by the PI and co-PIs, which span the fields of cell biology, parasitology, immunology, physiology, pathology, botany, and microbiology. Furthermore, a growing number of hands-on workshops are also expected to benefit from the FACS system. With its predominantly African-American population, Chicago State University is one of the largest minority serving institutions in the Midwest and has a growing number of programs aimed at enhancing underrepresented minority participation in basic science research and channeling B.Sc. and M.Sc. graduates into professional degree-granting institutions. As such, the impact of acquisition of a FACS is expected to translate into significant gains in recruitment and empowerment of minority students through academic and research training that incorporates up-to-date scientific and biomedical technology. This, in turn, will contribute to increased diversity in the American landscape of skilled professionals.

该奖项是为了收购荧光激活细胞分选仪（FACS），这将支持芝加哥州立大学生物科学系的研究，教学，课程改进和专业发展。FACS系统允许用户基于天然或实验引入的参数（包括细胞表面分子、遗传含量和一般细胞形状和大小）来识别和分选细胞亚群。PI和三种共同PI检查的细胞类型范围从哺乳动物肠道粘膜和免疫细胞（Drs Al-Ghoul和Swier）到原生动物（Dr Maselli）和植物原生质体（Dr Poturi）。该奖项的项目目标涉及与肠粘膜屏障，宿主-病原体相互作用，细胞囊泡运输以及环境保护和作物改良相关的基本细胞机制。这些教师及其学生对FACS的知识和使用的传播将确保获得FACS将对芝加哥州立大学的研究探索和培训环境产生重大影响，使其达到更符合当前研究和培训标准的水平。除了对芝加哥州立大学的科研环境产生巨大影响外，购置该系统是对教学、课程改进和专业发展所需的基础设施的一个重要补充。在基本层面上，预计将发挥核心作用，扩大探究式学习，促进学生合作，并提供先进技术的宝贵实践经验。这肯定会提高PI和co-PI教授或设计的课程的教学水平和质量，这些课程涵盖细胞生物学，寄生虫学，免疫学，生理学，病理学，植物学和微生物学等领域。此外，预计越来越多的实践讲习班也将受益于外地资产管制系统。 芝加哥州立大学以非洲裔美国人为主，是中西部最大的少数民族服务机构之一，并且有越来越多的项目，旨在提高代表性不足的少数民族参与基础科学研究，并引导B.Sc.和M.Sc.毕业生进入专业学位授予机构。 因此，购置外地资产管制系统的影响预计将转化为通过纳入最新科学和生物医学技术的学术和研究培训，在征聘和增强少数群体学生能力方面取得重大进展。反过来，这将有助于增加美国熟练专业人员的多样性。