MRI: Acquisition of a Fluorescence Activated Cell Sorting System to Expand Synergistic Research and Educational Opportunities

MRI：收购荧光激活细胞分选系统以扩大协同研究和教育机会

• 批准号: 1726645
• 负责人: Michael Robinson
• 金额: $ 25.61万
• 依托单位: Miami University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1726645&HistoricalAwards=false
• 关键词: MRI; Acquisition; Fluorescence; Activated; Cell

An award is made to Miami University for the acquisition of a fluorescence-activated cell sorting (FACS) system. The FACS system will expand synergistic research and educational opportunities in southwest Ohio. This instrument will enhance Miami University's substantial commitment to undergraduate education and community outreach at all levels of education and socioeconomic status. New undergraduate laboratory exercises will incorporate the use of hands-on cell sorting experiences using the new FACS system. Miami University will also use the FACS system to enrich several existing community outreach programs including Talawanda Science Week, designed to inspire local elementary school students to enter STEM fields, and the Cincinnati Museum Center STEM Girls Day Out program serving 8-14 year old girls from the eight county area surrounding Cincinnati, Ohio tri-state region. The FACS system will create a centerpiece to solicit partners from agriculture and industry in collaboration with the BioOhio organization that serves the needs of biotechnology-driven companies in Ohio. Miami University's Hefner Museum of Natural History will also create an interactive, student-curated exhibit to introduce the principles of cell sorting, and how cell sorting technology can advance multidisciplinary scientific inquiry.The FACS system will support a broad range of ongoing, interdisciplinary research that ranges from tissues, to organs, to ecological communities. Regeneration research supported by the FACS system, at Miami University, include programs designed at bioengineering retina, bone, adipose tissue and liver. The FACS system will also enhance current Miami University research programs investigating inflammation, neuronal survival following injury, mitochondrial metabolism and male reproductive physiology. Furthermore, the FACS system will open up new avenues of investigation supporting current ecological work at Miami University studying algae and abiotic stress, microbial metabolism, and climate change impacts on autotroph/heterotroph interactions in lake ecosystems. In addition to providing an essential tool for current research, the FACS system will also foster the development of new collaborations and research areas to support economic, intellectual, and educational development in the southwest Ohio region.

迈阿密大学因收购荧光激活细胞分选（流式细胞仪）系统而获奖。 FACS系统将扩大俄亥俄州西南部的协同研究和教育机会。这一工具将加强迈阿密大学对本科教育和各级教育和社会经济地位的社区推广的实质性承诺。新的本科生实验室练习将包括使用新的流式细胞仪系统进行细胞分选的实践经验。迈阿密大学还将使用FACS系统来丰富现有的几个社区外展计划，包括旨在激励当地小学生进入STEM领域的塔拉旺达科学周，以及辛辛那提博物馆中心STEM女孩外出计划，该计划为俄亥俄州三州地区辛辛那提周围八个县的8-14岁女孩提供服务。FACS系统将与生物俄亥俄州组织合作，为俄亥俄州生物技术驱动型公司的需求提供服务。迈阿密大学的赫夫纳自然历史博物馆也将创建一个互动的，学生策划的展览，介绍细胞分选的原则，以及细胞分选技术如何促进多学科的科学探究。流式细胞仪系统将支持广泛的正在进行的跨学科研究，范围从组织，器官，生态社区。由迈阿密大学的流式细胞仪系统支持的再生研究，包括在生物工程视网膜、骨骼、脂肪组织和肝脏方面设计的项目。流式细胞仪系统还将加强目前迈阿密大学的研究计划，调查炎症，损伤后的神经元存活，线粒体代谢和男性生殖生理学。此外，流式细胞仪系统将开辟新的调查途径，支持目前的生态工作在迈阿密大学研究藻类和非生物胁迫，微生物代谢，气候变化对湖泊生态系统中的自养/异养生物相互作用的影响。除了为当前的研究提供一个重要的工具，该系统还将促进新的合作和研究领域的发展，以支持经济，智力和教育发展西南俄亥俄州地区。

项目成果

Signalling lymphocyte activation molecule family member 9 is found on select subsets of antigen‐presenting cells and promotes resistance to Salmonella infection

信号淋巴细胞激活分子家族成员 9 存在于选定的抗原呈递细胞亚群中，可促进对沙门氏菌感染的抵抗力

• DOI: 10.1111/imm.13169
• 发表时间: 2020
• 期刊: Immunology
• 影响因子: 6.4
• 作者: Wilson, Timothy J.;Clare, Simon;Mikulin, Joseph;Johnson, Christopher M.;Harcourt, Katherine;Lyons, Paul A.;Dougan, Gordon;Smith, Kenneth G.
• 通讯作者: Smith, Kenneth G.

Generation of a Retina Reporter hiPSC Line to Label Progenitor, Ganglion, and Photoreceptor Cell Types

• DOI: 10.1167/tvst.9.3.21
• 发表时间: 2020-02-01
• 期刊: TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
• 影响因子: 3
• 作者: Lam, Phuong T.;Gutierrez, Christian;Robinson, Michael L.
• 通讯作者: Robinson, Michael L.