MRI: Acquisition of a Magnetic Resonance Microscope for a University Wide User Facility

MRI：为大学广泛用户设施购置磁共振显微镜

• 批准号: 0521595
• 负责人: Joseph Seymour
• 金额: $ 48.6万
• 依托单位: Montana State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2009-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0521595&HistoricalAwards=false
• 关键词: MRI; Acquisition; Magnetic; Resonance; Microscope

A 300 MHz wide bore nuclear magnetic resonance (NMR) micro-imaging system with a diffusion probe and a rheo-device will be acquired. This instrumentation is designed for Magnetic Resonance Microscopy (MRM), i.e. high spatial resolution magnetic resonance imaging (MRI), which allows investigation of flow, diffusion, and spatial variations in matter on spatial scales of the order of 10 micrometers spatially resolved, or 10 nm from statistical bulk measurements of molecular motion within a volume element and over timescales ranging from 10 microseconds to 1second. The acquired MRM system will provide a University wide MRM user facility where appropriate samples from any MSU research lab can be interrogated by MRM by a trained operator. The acquired MRM system will allow the execution of initiated projects on ice-soil-hydrocarbon interactions, on bio-polymer dynamics, and on the interaction of geochemistry, biological activity and hydrology in subglacial sediments. MRM microscopy methods allow noninvasive measurement of fluid dynamical, chemical and biological activity in natural systems, providing unique data for the development of conceptual and numerical models of systems in which hierarchies of scales play a role in the system physical, chemical and biological evolution.The MRM group is active in educational and outreach activities such as Expanding Your Horizons, a workshop aimed at female middle school students, and Montana Apprenticeship Program which is a summer internship program for disadvantaged Native American high school students. The MRM group prepares undergraduate and graduate students for careers in the fields of micro-fluidics and 'bio-engineering studies using MRI' through publication in journals, participation at international conferences and involvement in multi-disciplinary research teams. The research conducted by the group provides the ability to quantitatively measure dynamics and structure-function using MRM and has the potential to impact medical diagnostic imaging and bioremediation of environmentally contaminated sites providing benefit to society. The instrumentation will enhance University infrastructure for graduate and postdoctoral training activities by generating productive new projects and assist in achieving the MSU five-year plan of increasing graduate enrollment.

将获得一个300 MHz宽口径核磁共振（NMR）显微成像系统，配有扩散探头和流变仪。该仪器设计用于磁共振显微镜检查（MRM），即高空间分辨率磁共振成像（MRI），其允许在10微米空间分辨率或10 nm的空间尺度上对物质的流动、扩散和空间变化进行研究，从体积元素内的分子运动的统计批量测量和从10微秒到1秒的时间尺度。所收购的MRM系统将提供一个大学范围的MRM用户设施，在那里来自任何MSU研究实验室的适当样本可以由MRM由受过训练的操作员进行询问。收购的MRM系统将允许执行有关冰-土壤-碳氢化合物相互作用、生物聚合物动力学以及冰下沉积物中地球化学、生物活动和水文学相互作用的启动项目。MRM显微镜方法允许对自然系统中的流体动力学、化学和生物学活动进行非侵入性测量，为开发系统的概念和数值模型提供独特的数据，其中尺度层次在系统的物理、化学和生物进化中发挥作用。MRM小组积极参与教育和推广活动，例如针对女中学生的“拓展你的视野”研讨会，蒙大拿州学徒计划，这是一个针对弱势美洲土著高中学生的暑期实习计划。MRM小组通过在期刊上发表文章，参加国际会议和参与多学科研究团队，为本科生和研究生在微流体和“使用MRI的生物工程研究”领域的职业生涯做好准备。该小组进行的研究提供了使用MRM定量测量动态和结构功能的能力，并有可能影响环境污染场地的医学诊断成像和生物修复，为社会带来好处。该仪器将通过产生富有成效的新项目来加强研究生和博士后培训活动的大学基础设施，并协助实现MSU增加研究生入学率的五年计划。