SGER: Parallelized Hybrid Solid-State/Bio Microfabrication

SGER：并行混合固态/生物微加工

• 批准号: 0533100
• 负责人: Babak Parviz
• 金额: $ 6万
• 依托单位: University of Washington
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0533100&HistoricalAwards=false
• 关键词: SGER; Parallelized; Hybrid; Solid; State

The objective of this proposal is to develop a parallel microfabrication technology that allows for integration of inorganic materials and microstructures with mm-scale insects.Specifically, fruit fly is used as a model insect. Fruit fly embryos are self-assembled into a patterned substrate via fluidic self-assembly to form an array. They are encapsulated inmicrochambers and the development cycle is allowed to progress. The development is halted in the larva stage to perform a microfabrication step, for example metal evaporation, onto the larvae in the microchambers and then the insect development cycle is allowed to proceed. This technology allows for modification of mm-scale insects in a massively parallel fashion. In future extensions it can be used to incorporate control/RF circuitry or sensors into the structure of colonies of insects. Intellectual Merits:This project develops a novel hybrid manufacturing method that combines biology and solid-state microfabrication. It provides the first example of direct microfabrication on a live and functional insect. The project will establish the possibilities and limits of parallel solid-state processing on insects at various levels of their development and will demonstrate a massively parallel method to modify a large collection of biological entities.Broader Impact:The project directly contributes to training of students at the interface between biology and solid-state fabrication.

本研究的目的是开发一种并行微加工技术，将无机材料和微结构与毫米级昆虫集成在一起，特别是以果蝇为模型昆虫。通过流体自组装将果蝇胚胎自组装到图案化基底中以形成阵列。它们被封装在微室中，并允许开发周期进行。在幼虫阶段停止发育，以在微室中的幼虫上进行微加工步骤，例如金属蒸发，然后允许昆虫发育周期继续进行。该技术允许以大规模并行方式修改mm级昆虫。在未来的扩展中，它可以用于将控制/RF电路或传感器结合到昆虫群体的结构中。智力优势：该项目开发了一种新的混合制造方法，结合了生物学和固态微制造。它提供了第一个在活的和功能性昆虫上直接微制造的例子。 该项目将确定在昆虫发育的各个阶段进行并行固态加工的可能性和限制，并将展示一种大规模并行方法来修改大量生物实体。更广泛的影响：该项目直接有助于培养学生在生物学和固态制造之间的接口。