Metacognition and memory in obsessive-compulsive disorder

患有强迫症（OCD）的受试者在标准记忆测试中表现出受损，尤其是在需要主动编码的情况下。然而，很难将这些发现与强迫症的精神病理症状联系起来，也很难将神经心理缺陷的发现纳入强迫症的疾病模型。功能失调的元认知信念和元认知调节过程越来越被认为是强迫症认知脆弱性的一部分。在本项目的第一部分，我们成功地建立了一个新的实验范式来操纵认知自我意识，这是强迫症功能失调元认知调节的一个重要方面。我们可以证明，高认知自我意识对情景记忆编码的影响正在恶化。然而，强迫症的元认知调节功能障碍是否与已知的强迫症额纹状体回路功能障碍有关，或者是否需要将在注意力分配中起作用的额顶叶回路纳入强迫症的神经生物学模型中，目前尚不清楚。本研究旨在探讨不同注意焦点下记忆编码的功能神经关联。先前建立的实验学习程序将用于功能磁共振成像研究。

Subjects with obsessive-compulsive disorders (OCD) have been shown to be impaired on standard memory tests, especially if active encoding is required. However, it has proved difficult to related these findings to psychopathological symptoms of OCD and to incorporate findings of neuropsychological deficits into OCD disease models.Dysfunctional metacognitive beliefs and metacognitive regulation processes are increasingly recognized as part of the cognitive vulnerability for OCD.In the first part of this project we succeeded in establishing a new experimental paradigm for manipulating cognitive self-consciousness, which is one important aspect of dysfunctional metacognitive regulation in OCD. We could prove that high cognitive self-consciousness has a deteriorating influence on episodic memory encoding. However, it is still unknown whether dysfunctional metacognitive regulation in OCD is related to the known dysfunction of fronto-striatal circuits in OCD or whether further fronto-parietal circuits, which play a role in attention allocation, have to be incorporated into a neurobiological model of OCD.The current proposal aims at investigating the functional neural correlates of memory encoding under different attentional focus. The previously established experimental learning procedure will be used in a fMRI investigation.