PECASE: Bioengineering of Secondary Metabolic Pathways
PECASE:次级代谢途径的生物工程
基本信息
- 批准号:0545860
- 负责人:
- 金额:$ 40万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-07-01 至 2011-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Tang0545860Tetracyclines have been prescribed as broad-spectrum antibiotics and have recently been used in anticancer therapies. The objective of this research is to understand the metabolic pathway, the molecular assembly, and the combinatorial potential of tetracycline biosynthesis. Four specific aims will be pursued: (1) Reconstitute and understand the assembly of the amidated tetracycline backbone; (2) Reconstitute the first tetracyclic intermediate in oxytetracycline (oxy) pathway and use metabolic engineering to produce a novel C8-hydroxylated analog of the intermediate; (3) Reconstitute the tailoring steps in oxy pathway and construct a series of strains that can produce valuable metabolic intermediates; (4) Engineered biosynthesis of novel glycosylated analogs of tetracycline through shuffling of heterologous secondary metabolic pathways. The research and education efforts will be integrated through the following mechanisms: 1) Two recently developed, core biotechnology courses will be enriched to increase critical thinking and active learning by the students; 2) Community outreach will be emphasized by inviting underprivileged minority students in the greater Los Angeles metropolitan area to learn research during the summer months, as well as participating in university-community events to promote science education and life-long learning.
四环素类药物已被处方为广谱抗生素,最近已用于抗癌治疗。 本研究的目的是了解四环素生物合成的代谢途径,分子组装和组合潜力。 本论文的主要目标是:(1)重构并理解酰胺化四环素骨架的组装;(2)重构土霉素(oxytetracycline,oxy)途径中的第一个四环中间体,并利用代谢工程技术生产新的四环中间体的C8-羟基化类似物;(3)重构oxytetracycline途径中的剪裁步骤,构建一系列能产生有价值的代谢中间体的菌株;(4)通过异源次级代谢途径的改组工程化生物合成新型糖基化四环素类似物。 将通过以下机制将研究和教育工作结合起来:1)将充实两门最近开发的核心生物技术课程,以提高学生的批判性思维和主动学习能力; 2)社区外展将通过邀请大洛杉矶都市区的贫困少数民族学生在夏季学习研究来强调,以及参与大学与社区合办的活动,以推广科学教育和终身学习。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Yi Tang其他文献
Nickel-doped Co4N nanowire bundles as efficient electrocatalysts for oxygen evolution reaction
镍掺杂Co4N纳米线束作为析氧反应的高效电催化剂
- DOI:
10.1007/s40843-020-1590-x - 发表时间:
2021-02 - 期刊:
- 影响因子:0
- 作者:
Dan Li;Wenbiao Zhang;Jiachang Zeng;Boxu Gao;Yi Tang;Qingsheng Gao - 通讯作者:
Qingsheng Gao
SiC and GaN bipolar power devices
SiC 和 GaN 双极功率器件
- DOI:
- 发表时间:
2000 - 期刊:
- 影响因子:0
- 作者:
T. Chow;V. Khemka;J. Fedison;N. Ramungul;K. Matocha;Yi Tang;R. Gutmann - 通讯作者:
R. Gutmann
Recent decrease trend of atmospheric mercury concentrations in East China: the influence of anthropogenic emissions
近期华东地区大气汞浓度下降趋势:人为排放的影响
- DOI:
10.5194/acp-18-8279-2018 - 发表时间:
2018-06 - 期刊:
- 影响因子:6.3
- 作者:
Yi Tang;Shuxiao Wang;Qingru WU et al. - 通讯作者:
Qingru WU et al.
A two-stage deep transfer learning for localisation of forced oscillations disturbance source
用于强迫振荡干扰源定位的两阶段深度迁移学习
- DOI:
10.1016/j.ijepes.2021.107577 - 发表时间:
2022-02 - 期刊:
- 影响因子:5.2
- 作者:
Shuang Feng;Jianing Chen;Yujian Ye;Xi Wu;Hao Cui;Yi Tang;Jiaxing Lei - 通讯作者:
Jiaxing Lei
[Association between development of hypertension and nutrition in school-age children in Fengdu County of Chongqing, China].
重庆市丰都县学龄儿童高血压发生与营养的关系[J].
- DOI:
- 发表时间:
2016 - 期刊:
- 影响因子:0
- 作者:
Su;Xiaohua Liang;Ting Yang;Jiapei Xu;Yi Tang;Youxue Liu;Jie Chen - 通讯作者:
Jie Chen
Yi Tang的其他文献
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{{ truncateString('Yi Tang', 18)}}的其他基金
Discovery and Characterization of SAM-Dependent Pericyclases
SAM 依赖性周环酶的发现和表征
- 批准号:
1806581 - 财政年份:2018
- 资助金额:
$ 40万 - 项目类别:
Standard Grant
Collaborative Research: SusChEM: A Robust Yeast Platform for the Synthesis and Engineering of Polyketide-Based Pharmaceuticals and Chemicals
合作研究:SusChEM:用于聚酮化合物药物和化学品合成和工程的强大酵母平台
- 批准号:
1605877 - 财政年份:2016
- 资助金额:
$ 40万 - 项目类别:
Standard Grant
Collaborative Research: Metabolite-responsive regulators for polyketide pathway engineering
合作研究:聚酮化合物途径工程的代谢物响应调节剂
- 批准号:
1159759 - 财政年份:2012
- 资助金额:
$ 40万 - 项目类别:
Continuing Grant
Biosynthetic Engineering Approaches towards Generating New Tetracycline Antibiotics
生成新型四环素抗生素的生物合成工程方法
- 批准号:
1033070 - 财政年份:2010
- 资助金额:
$ 40万 - 项目类别:
Standard Grant
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