CAREER: Next-Generation Research and Education in Therapeutic Optimization

该学院早期职业发展（Career）研究涉及下一代治疗优化，包括构建疾病进展的定量模型，以及优化一套特定的治疗方法。这项提案的学术价值集中在终末期肝病的三个广泛领域，终末期肝病是美国的主要杀手之一，但这项研究也适用于其他疾病。第一个广泛的领域解决了在传统运筹学应用中不常见的治疗优化问题，并描述了解决其中三个问题的方法。第二个广泛的领域描述了如何使用考虑患者观点的模型来解决政策问题。第三个广泛的领域，也许是最雄心勃勃的，考虑整合患者和社会观点的肝脏分配机制。这项工作的广泛影响将直接影响成千上万的终末期肝病患者，并通过治疗优化领域的重大改进间接影响数百万人。该教育计划将直接影响四个群体：医学研究人员，主要是医学博士；将最先进的运筹学技术应用于复杂和现实医疗问题的博士生；本科生和研究人员；还有高中生。研究和教育计划很好地结合在一起，一方的进展将有助于另一方。

This Faculty Early Career Development (CAREER) research addresses next-generation therapeutic optimization, which involves constructing quantitative models of disease progression, and optimizing a particular set of therapies. The intellectual merit of this proposal focuses on three broad areas in end-stage liver disease, one of the leading killers in the United States, but the research applies to other diseases as well. The first broad area addresses issues that arise in therapeutic optimization that are uncommon in traditional operations research applications, and describes methods to address three of these. The second broad area describes how models that consider the patient's perspective can be used to address policy questions. The third broad area, perhaps the most ambitious, considers liver allocation mechanisms that integrate the patient's and societal perspectives. The broader impacts of the proposed work will be felt directly by thousands of end-stage liver disease patients, and indirectly by millions more through significant improvements in the field of therapeutic optimization. The educational plan will directly impact four groups: medical researchers, primarily MDs; PhD students who apply state-of-the-art operations research techniques to complex and realistic medical problems; undergraduate students and researchers; and high school students. The research and educational plans are well integrated, and progress in one will aid the other.