Molecular mechanisms for seminal fluid signalling in reproduction

生殖精液信号传导的分子机制

• 批准号: DP0986882
• 负责人: Prof Sarah Robertson
• 金额: $ 32.56万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0986882
• 关键词: Molecular; mechanisms; seminal; fluid; signalling

Male seminal fluid regulation of the female reproductive process influences fertility and fecundity in humans and animal species. Infertility and impaired reproductive function is a major economic constraint in livestock industries, and carries a substantial social and public health cost in humans. This research will identify the active signalling molecules in seminal fluid and quantify their importance in reproductive success and health of offspring. The outcomes will inform development of new diagnostic assays for male fertility, and underpin strategic design of novel fertility treatments and products with applications in the human health and animal breeding industries.

男性精液对女性生殖过程的调节影响人类和动物物种的生育力和繁殖力。 不育和生殖功能受损是畜牧业的主要经济制约因素，并给人类带来巨大的社会和公共卫生成本。 这项研究将确定精液中的活性信号分子，并量化它们在生殖成功和后代健康中的重要性。 研究结果将为男性生育力的新诊断方法的开发提供信息，并为人类健康和动物养殖行业应用的新型生育治疗和产品的战略设计提供支持。