Male to female sperm signalling – a new role for sperm in reproduction?

男性精子向女性发出信号——精子在生殖中的新作用？

• 批准号: DP160102366
• 负责人: Prof Sarah Robertson
• 金额: $ 30.34万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160102366
• 关键词: Male; female; sperm; signalling; new

Male seminal fluid is commonly thought simply to provide sperm for conception. This project aims to investigate a lesser known action of sperm: modifying the female immune response to increase the chances of reproductive success. The project aims to define the molecular pathway through which sperm interact with female cells, particularly how B-defensins on sperm bind to Toll-like receptors to stimulate female immune tolerance. The project plans to use embryo transfer and genetic mouse models to determine the physiological benefit of sperm signalling. Evidence that seminal fluid signalling operates in mammals to ensure optimal female reproductive investment would advance knowledge of the male contribution to the reproductive process.

男性精液通常被认为只是为受孕提供精子。该项目旨在研究精子的一个鲜为人知的作用：修改女性免疫反应以增加生殖成功的机会。该项目旨在确定精子与女性细胞相互作用的分子途径，特别是精子上的B-防御素如何与Toll样受体结合以刺激女性免疫耐受。该项目计划使用胚胎移植和遗传小鼠模型来确定精子信号的生理益处。有证据表明，精液信号在哺乳动物中起作用，以确保最佳的女性生殖投资，将促进男性对生殖过程的贡献的知识。