Seminal fluid interferon-gamma: a potential inhibitor of reproductive success

精液干扰素-γ：生殖成功的潜在抑制剂

• 批准号: DP190103694
• 负责人: Prof Sarah Robertson
• 金额: $ 34.39万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-02-11 至 2022-02-10
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190103694
• 关键词: Seminal; fluid; interferon; gamma; potential

This project aims to investigate mechanisms by which infection, heat stress and psycho-social stress interfere with fertility by inducing a signalling factor in seminal fluid that suppresses female immune adaptation for pregnancy. Factors in seminal fluid in addition to sperm parameters are known to affect male reproductive success, but these are not well defined. The cytokine interferon-gamma (IFNG) is variably present in seminal plasma of several mammalian species. It was recently discovered that IFNG interferes with the female immune response required for reproductive success. This project will investigate how seminal fluid IFNG alters female immune adaptation for pregnancy. This will define how environmental factors induce seminal fluid IFNG and determine whether inhibitory effects of IFNG can be overcome with pharmacological inhibitors to boost reproductive success.

该项目旨在调查感染、热应激和心理社会应激通过在精液中诱导抑制女性怀孕免疫适应的信号因子而干扰生育的机制。众所周知，除了精子参数之外，精液中的因素也会影响男性生殖成功，但这些因素还没有得到很好的定义。细胞因子干扰素-γ（IFNG）在几种哺乳动物的精浆中大量存在。最近发现IFNG干扰生殖成功所需的女性免疫反应。本项目将研究精液IFNG如何改变女性怀孕的免疫适应。这将确定环境因素如何诱导精液IFNG，并确定IFNG的抑制作用是否可以用药物抑制剂克服，以促进生殖成功。