Seminal transforming growth factor (TGF) beta, maternal immune tolerance and pregnancy outcome

精液转化生长因子（TGF）β、母体免疫耐受和妊娠结局

• 批准号: nhmrc : 104837
• 负责人: Prof Sarah Robertson
• 金额: $ 18.5万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/seminal-transforming-growth-pregnancy-outcome/95374
• 关键词: Seminal; transforming; growth; factor; TGF

This study aims to determine the extent to which semen is important in initiating the maternal immune response to the fetus and placenta during pregnancy. We postulate that exposure to paternal proteins in sperm and other factors present in the semen may have a cumulative, beneficial effect in 'educating' the female immune system to respond in the correct way to the embryo when pregnancy occurs. To investigate this, the behaviour and movements of white blood cells responding to semen will be studied during the period after mating, in which the uterus prepares for and accommodates to pregnancy. In particular, the study will focus on the roles of a specific chemical messenger substance in semen, called transforming growth factor (TGF)-beta, which triggers the molecular changes leading to maternal immune tolerance. A deeper understanding of these events will have an important impact in human and veterinary medicine where implantation failure is a major cause of reproductive loss and inadequate placental growth poses a threat to the health of the conceptus both in utero and into adult life.

本研究旨在确定精液在妊娠期间启动母体对胎儿和胎盘的免疫反应中的重要程度。我们假设，暴露于精子中的父亲蛋白质和精液中存在的其他因素可能会产生累积的有益影响，“教育”女性免疫系统在怀孕时以正确的方式对胚胎做出反应。为了研究这一点，将在交配后的一段时间内研究白色血细胞对精液的反应行为和运动，在这段时间内，子宫为怀孕做准备并适应怀孕。特别是，该研究将重点关注精液中一种特定的化学信使物质的作用，称为转化生长因子（TGF）-β，它触发了导致母体免疫耐受的分子变化。对这些事件的深入了解将对人类和兽医学产生重要影响，其中着床失败是生殖损失的主要原因，胎盘生长不足对子宫内和成年后的孕体健康构成威胁。