Multiscale Coarse-Grained Modeling with Experimental Verification of DNA-Carbon Nanotube Complexes
DNA-碳纳米管复合物的多尺度粗粒度建模及实验验证
基本信息
- 批准号:0600661
- 负责人:
- 金额:$ 25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-08-15 至 2008-04-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The goal of the proposed research is to uncover the underlying interaction mechanisms between carbon nanotubes (CNTs) and DNA molecules through an integrated experimental and modeling approach. DNA-CNT complexes, benefiting from both the unique electro-mechanical properties of CNTs and the specific molecular recognition capabilities of the immobilized single-stranded DNA, hold great promise for bio-molecular detection and gene delivery applications. Despite considerable prior experimental efforts, the DNA-CNT interface is still poorly understood, greatly limiting the reliability and the efficiency of such novel applications. The proposed research will significantly enhance our current knowledge of the DNA-CNT interface, and will pave the way toward the realization of high-sensitivity miniaturized DNA-CNT based biosensors. The complementary educational plan will greatly increase both the general public's awareness of nanotechnology-based biomedical applications and the participation of young investigators in the exciting field of nanobiotechnology.
该研究的目标是通过实验和建模相结合的方法,揭示碳纳米管(CNTs)和DNA分子之间的相互作用机制。DNA-CNT复合物,受益于碳纳米管独特的机电性能和固定化单链DNA的特异性分子识别能力,在生物分子检测和基因递送应用中具有很大的前景。尽管之前进行了大量的实验努力,但对DNA-CNT界面的了解仍然很少,这极大地限制了这种新应用的可靠性和效率。这项研究将大大提高我们目前对DNA-CNT界面的认识,并为实现高灵敏度的小型化DNA-CNT生物传感器铺平道路。 该补充教育计划将大大提高公众对纳米技术生物医学应用的认识,并促进年轻研究人员参与纳米生物技术这一令人兴奋的领域。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Sulin Zhang其他文献
Foam pad of appropriate thickness can improve diagnostic value of foam posturography in detecting postural instability
适当厚度的泡沫垫可以提高泡沫姿势描记法检测姿势不稳定性的诊断价值
- DOI:
- 发表时间:
2018 - 期刊:
- 影响因子:1.4
- 作者:
Bo Liu;Y. Leng;Ren;Jing;Dongdong Liu;Jia Liu;Sulin Zhang;W. Kong - 通讯作者:
W. Kong
Effective coarse-grained simulations of super-thick multi-walled carbon nanotubes under torsion
扭转下超厚多壁碳纳米管的有效粗粒度模拟
- DOI:
10.1063/1.3074285 - 发表时间:
2009 - 期刊:
- 影响因子:3.2
- 作者:
Jian Zou;X. R. Huang;M. Arroyo;Sulin Zhang - 通讯作者:
Sulin Zhang
Age-related decline in CD8+ tissue resident memory T cells compromises antitumor immunity
与年龄相关的 CD8+组织驻留记忆 T 细胞的减少损害了抗肿瘤免疫力
- DOI:
10.1038/s43587-024-00746-5 - 发表时间:
2024-11-26 - 期刊:
- 影响因子:19.400
- 作者:
Siyu Pei;Xiuyu Deng;Ruirui Yang;Hui Wang;Jian-Hong Shi;Xueqing Wang;Jia Huang;Yu Tian;Rongjing Wang;Sulin Zhang;Hui Hou;Jing Xu;Qingcheng Zhu;Huan Huang;Jialing Ye;Cong-Yi Wang;Wei Lu;Qingquan Luo;Zhi-Yu Ni;Mingyue Zheng;Yichuan Xiao - 通讯作者:
Yichuan Xiao
Two quantum mechanical/molecular mechanical coupling schemes appropriate for fracture mechanics studies
适用于断裂力学研究的两种量子力学/分子力学耦合方案
- DOI:
10.2514/6.2007-2171 - 发表时间:
2007 - 期刊:
- 影响因子:0
- 作者:
R. Khare;S. L. Mielke;Jeffrey T. Paci;Sulin Zhang;G. Schatz;T. Belytschko - 通讯作者:
T. Belytschko
Chemomechanical modeling of lithiation-induced failure in high-volume-change electrode materials for lithium ion batteries
- DOI:
10.1038/s41524-017-0009-z - 发表时间:
2017-02 - 期刊:
- 影响因子:9.7
- 作者:
Sulin Zhang - 通讯作者:
Sulin Zhang
Sulin Zhang的其他文献
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{{ truncateString('Sulin Zhang', 18)}}的其他基金
Collaborative Research: Creep-enabled 3D solid-state Lithium-metal batteries
合作研究:可蠕变的 3D 固态锂金属电池
- 批准号:
2034899 - 财政年份:2020
- 资助金额:
$ 25万 - 项目类别:
Standard Grant
Skin-Inspired Mechanics of Liquid Metal - Elastomer Composites as Super Soft, Stretchable, and Tough Conductors
液态金属的皮肤力学 - 弹性体复合材料作为超软、可拉伸和坚韧的导体
- 批准号:
1933398 - 财政年份:2019
- 资助金额:
$ 25万 - 项目类别:
Standard Grant
Collaborative Research: Electrochemically driven Mechanical Energy Harvesting
合作研究:电化学驱动的机械能量收集
- 批准号:
1610331 - 财政年份:2016
- 资助金额:
$ 25万 - 项目类别:
Standard Grant
Multiscale Modeling of Defect Rearrangement and Removal in 2D Layered Crystals
二维层状晶体中缺陷重排和去除的多尺度建模
- 批准号:
1462980 - 财政年份:2015
- 资助金额:
$ 25万 - 项目类别:
Standard Grant
Understanding the Failure Mechanisims of Nanoelectrodes in Li-Ion Batteries: Integrating Multiscale Modeling with In-situ Experimental Studies
了解锂离子电池纳米电极的失效机制:将多尺度建模与原位实验研究相结合
- 批准号:
1201058 - 财政年份:2012
- 资助金额:
$ 25万 - 项目类别:
Standard Grant
Collaborative Research: Developing A Complete Membrane-Cytoskeleton Model for Human Erythrocyte
合作研究:开发完整的人类红细胞膜细胞骨架模型
- 批准号:
1067523 - 财政年份:2011
- 资助金额:
$ 25万 - 项目类别:
Continuing Grant
Perfecting Monolayer Graphene by Defect Removal Using Novel Thermo-Mechanical Methods
使用新型热机械方法去除缺陷来完善单层石墨烯
- 批准号:
0900692 - 财政年份:2009
- 资助金额:
$ 25万 - 项目类别:
Standard Grant
CAREER: Multiscale Modeling of Nanoparticle-Cell Interactions
职业:纳米颗粒-细胞相互作用的多尺度建模
- 批准号:
0644599 - 财政年份:2007
- 资助金额:
$ 25万 - 项目类别:
Standard Grant
CAREER: Multiscale Modeling of Nanoparticle-Cell Interactions
职业:纳米颗粒-细胞相互作用的多尺度建模
- 批准号:
0754463 - 财政年份:2007
- 资助金额:
$ 25万 - 项目类别:
Standard Grant
Multiscale Coarse-Grained Modeling with Experimental Verification of DNA-Carbon Nanotube Complexes
DNA-碳纳米管复合物的多尺度粗粒度建模及实验验证
- 批准号:
0826841 - 财政年份:2007
- 资助金额:
$ 25万 - 项目类别:
Standard Grant
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