Functional dissociation of octopamine and tyramine receptors in regulationg honey bee division of labour

章鱼胺和酪胺受体在调节蜜蜂分工中的功能分离

• 批准号: 175437369
• 负责人: Professorin Dr. Ricarda Scheiner-Pietsch
• 金额: --
• 依托单位: Lehrstuhl für Verhaltensphysiologie und Soziobiologie (Zoologie II)
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2013-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/175437369?language=en
• 关键词: Functional; dissociation; octopamine; tyramine; receptors

The aim of the proposed project is to dissociate the roles of octopamine and tyramine receptors in regulating division of labour in honey bees. A prominent current hypothesis assumes that division of labour is based on individual differences in response thresholds for task-related stimuli. Therefore, we will analyse in detail the function of the amine receptors in controlling sensory responsiveness. To achieve these goals, four objectives are put forward.OBJECTIVE 1 is to determine the relationships between the expression of octopamine and tyramine receptor genes, octopamine and tyramine titres in brain compartments, sensory response thresholds and division of labour.OBJECTIVE 2 is to determine if octopamine and tyramine receptor gene expression is a dynamic and reversible function of social role in honey bees.OBJECTIVE 3 is to determine if interference with genes encoding for octopamine and tyramine receptors affects sensory response thresholds and division of labour.OBJECTIVE 4 is to analyse the role of social stimuli for division of labour and the biogenic amine system.These experiments will reveal the interplay of octopamine and tyramine receptors in regulating sensory responsiveness and division of labour in honey bees. They will be the first to differentiate the roles of individual octopamine and tyramine receptors in the social organization of insect societies.

该项目的目的是分离章鱼胺和酪胺受体在调节蜜蜂劳动分工中的作用。当前一个突出的假设是，劳动分工是基于对任务相关刺激的反应阈值的个体差异。因此，我们将详细分析胺受体在控制感觉反应中的功能。为了实现这些目标，提出了四个目标：目标1是确定脑区室中章鱼胺和酪胺受体基因的表达与章鱼胺和酪胺滴度之间的关系，目的2是确定章鱼胺和酪胺受体基因表达是否是蜜蜂社会角色的动态和可逆功能。目的3是确定章鱼胺和酪胺受体基因表达是否是蜜蜂社会角色的动态和可逆功能。干扰编码章鱼胺和酪胺受体的基因会影响蜜蜂的感觉反应阈值和分工，目的4分析社会刺激对蜜蜂分工和生物胺系统的作用，揭示章鱼胺和酪胺受体在调节蜜蜂感觉反应和分工中的相互作用。他们将是第一个区分个体章鱼胺和酪胺受体在昆虫社会组织中的作用。