Regulation of hematogenous ans lymph node tumor metastisis by acid sphingomyelinase
Regulation of hematogenous ans lymph node tumor metastisis by acid sphingomyelinase
批准号:
175469914
负责人:
Professor Dr. Erich Gulbins
金额:
$0.0万
依托单位国家:
德国
项目类别:
Research Grants
财政年份:
2010
资助国家:
德国
项目状态:
已结题
起止时间:
2009-12-31 至 2014-12-31
中文摘要
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英文摘要
Unsere Daten zeigen, dass Tumorzellen in Thrombozyten über eine Aktivierung und Sekretion der sauren Sphingomyelinase (Asm) Ceramid bilden und Integrine aktivieren. Hämatogene und lymphogene Tumormetastasierung ist in Asm-defizienten Mäusen um ca. 95% vermindert. Im vorliegenden Projekt untersuchen wir, über welche molekularen Mechanismen a) Melanomzellen die Asm in Plättchen aktivieren und die Sekretion des Enzyms vermitteln, b) sezernierte Asm Tumorzellen aktiviert und c) welche Rolle die Asm bei lymphogener Metastasierung von Melanomen spielt.
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海外基金