NER: Microfluidic-Enabled Synthesis of Nanoparticles and Hierarchical NanoClusters

NER：微流控纳米粒子和分层纳米团簇的合成

• 批准号: 0608864
• 负责人: Shelley Anna
• 金额: --
• 依托单位: Carnegie-Mellon University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0608864&HistoricalAwards=false
• 关键词: NER; Microfluidic; Enabled; Synthesis; Nanoparticles

National Science Foundation - Active Nanostructure and Nanosystems (ANN) (NSF 05-610)Nanoscale Exploratory Research (NER)ABSTRACTProposal Number: 0608864Principal Investigator: Anna, ShelleyAffiliation: Carnegie Mellon UniversityNER: Microfluidic-Enabled Synthesis of Nanoparticles and Heirarchial NanoClustersThis grant is to develop a new type of microfluidic-based technique for formation of metal and semiconductor nanoparticles. A novel, hierarchical and active manufacturing process in which highly monodisperse nanoparticles can be produced in a continuous and robust fashion will be developed. The method centers on recent microfluidic emulsification methods, but exploits the presence of surfactants at liquid-liquid interfaces to bring about the formation of droplets orders of magnitude smaller than the host device. Specifically, the tipstreaming phenomenon will be used to produce a continuous stream of submicron droplets. The reactant streams for nanoparticle synthesis will be encapsulated in the resulting submicron droplets, and will subsequently react to form highly monodisperse nanoparticles (1-10 nm) within the droplets. Two key advantages of using submicron droplets as nanoparticle reactors are that (1) submicron length scales allow for very effective diffusive mixing, minimizing the need for additional mixing schemes and enabling reaction kinetics to be isolated, and (2) resulting tiny reactor volumes lead to limited reactant supply within a single nanoreactor, allowing precise control over the number and size of nanoparticles formed. Furthermore, the ability to easily tune flow and reaction conditions inline in microfluidic devices leads to an inherently active nanoscale process. The fundamental knowledge gained from these studies will significantly contribute to a growing body of knowledge in the area of microreactor and nanoparticle technology. The results of this exploratory research will enable additional nanomanufacturing processes for synthesis of other novel nanostructures, including nano-alloys and nano-clusters controlled by the formation of concentric or sequential droplet reactors, high throughput screening devices for systematic, combinatorial study of nanoparticle chemistries, and the use of nanostructured hydrogels within submicron reactors to enhance nanoparticle uniformity while minimizing aggregation. The broader impacts of this work include the significant potential for the proposed method to realize wide application. In particular, a wide range of possible materials and chemistries can be utilized with this method, and a wide range of novel nanostructures can be synthesized. In addition, educational and outreach activities of the PI's will center on dispelling common misconceptions about nanotechnology, and will utilize the highly visual nature of microfluidics to appeal to audiences that are diverse in age, gender, and ethnicity.

国家科学基金会-主动纳米结构和纳米系统（ANN）（NSF 05 - 610）纳米尺度探索性研究（NER）摘要提案编号：0608864主要研究员：安娜，雪莱隶属关系： 卡内基梅隆大学：微流体使能的纳米粒子合成和继承性纳米粒子这个补助金是开发一种新型的基于微流体的技术，用于形成金属和半导体纳米粒子。 将开发一种新型的、分层的和主动的制造工艺，其中可以以连续和稳健的方式生产高度单分散的纳米颗粒。 该方法以最近的微流体乳化方法为中心，但利用了液-液界面处表面活性剂的存在，以形成比主机设备小几个数量级的液滴。具体而言，尖端流现象将用于产生亚微米液滴的连续流。用于纳米颗粒合成的反应物流将被封装在所得亚微米液滴中，并且随后将反应以在液滴内形成高度单分散的纳米颗粒（1 - 10 nm）。使用亚微米液滴作为纳米颗粒反应器的两个关键优点是（1）亚微米长度尺度允许非常有效的扩散混合，最小化对额外混合方案的需要并使得反应动力学能够被隔离，以及（2）所得微小反应器体积导致单个纳米反应器内有限的反应物供应，允许精确控制形成的纳米颗粒的数量和尺寸。此外，在微流体装置中容易地在线调节流动和反应条件的能力导致固有的活性纳米级过程。从这些研究中获得的基础知识将大大有助于微反应器和纳米颗粒技术领域不断增长的知识体系。这一探索性研究的结果将使其他nanomanufacturing工艺的合成其他新的纳米结构，包括纳米合金和纳米簇控制的形成同心或顺序液滴反应器，高通量筛选设备的系统，组合研究纳米粒子化学，和使用纳米结构的水凝胶在亚微米反应器，以提高纳米粒子的均匀性，同时最大限度地减少聚集。这项工作的更广泛的影响包括所提出的方法实现广泛应用的巨大潜力。特别是，广泛的可能的材料和化学物质可以利用这种方法，并且可以合成广泛的新型纳米结构。 此外，PI的教育和外展活动将集中在消除对纳米技术的常见误解，并将利用微流体的高度视觉特性来吸引年龄，性别和种族多样化的观众。