NER: Nano-Biodevices for Reliable, Long-Term Stimulation and Recording of Neural Activity

[608892] menner应用的目标是开发用于记录和刺激神经的可靠且持久的纳米生物装置。这一探索性建议涉及到一些关键问题。这些问题包括金纳米线的尺寸，细胞生长和运动伪影，以及细胞在电极-细胞界面的活力。该研究计划要求制造50nm、100nm和200nm三种尺寸的纳米线阵列。测量将通过培养两种类型的神经（大鼠海马和人类神经母细胞瘤）细胞到金和肽共轭金纳米线的表面来进行。

0608892MenonThe goal of this NER application is to develop nano-biodevices for recording and stimulating nerves that are reliable and long lasting. This exploratory proposal addresses some of the critical issues entailed. These issues include gold nano-wire size, cell growth and motion artifacts, and cell viability at the electrode-cell interface. The research plan calls for fabrication of an array of nano-wires in three sizes ranging of 50, 100, and 200 nm. Measurements will be performed by culturing two types of neural (rat hippocampal and human neuroblastoma) cells onto the surface of Au and peptide conjugated Au nano-wires.