SGER: Nanowire Array Technologies for Neural Recording Applications

SGER：用于神经记录应用的纳米线阵列技术

• 批准号: 0738294
• 负责人: Latika Menon
• 金额: $ 6.52万
• 依托单位: Northeastern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-15 至 2008-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0738294&HistoricalAwards=false
• 关键词: SGER; Nanowire; Array; Technologies; Neural

Latika MenonThe objective of this SGER is to develop an advanced nanodevice for recording electrical activity in neurons. The device will consist of an array of conducting nanowire arrays which will record electrical signals from neurons at the nanoscale level. This will provide a fundamental understanding of learning and memory processes in neurons and will lead to important clinical applications in neural implants and future brain machine interface devices. Intellectual Merit:This SGER has many features that will be very useful for learning about recording electrical activity in neurons. This will be the first demonstration of a nanowire-array based device which will allow recording of electrical activity from simultaneous locations in a single neuron thus leading to high spatial resolution. In addition, nanowires will cause minimal damage to the cell due to their small size with respect to the neuron (typically of the order of several microns). This research will provide an excellent integration of nano/microfabrication with biology, laying the groundwork for other novel devices in the future using similar principles. Use of nanowire-arrays for electrical recording from neurons is clearly a novel approach opening a number of possibilities for studying neuronal activity at the nanoscale level. The nanowire-neuron device proposed here will be a model system to study biophysical interactions between nanowires and cells. Nanowires provide the platform for functionalization with appropriate biorecognition molecules, ensuring cell immobilization and a more stable 'cell-attached' electrical recording. Broad Impact: Due to the small size of the nanowires with respect to the neuron sizes our device will allow a fundamental understanding of neuronal functions which will impact our understanding of changes in neural circuits that underlie neurological disorders and stroke. A more direct impact of our work will be related to a fundamental understanding of cell interaction with nano-environment which will relate not only to neurons but also to other cells such as cancer cells, stem cells, etc. In the area of education, one graduate student will be involved in the work and the project will lead to development of new laboratory facilities, particularly those pertaining to cell culture and cell characterization.

Latika Menon 该 SGER 的目标是开发一种先进的纳米设备来记录神经元的电活动。该设备将由一系列导电纳米线阵列组成，它将记录来自纳米级神经元的电信号。这将为神经元的学习和记忆过程提供基本的理解，并将导致神经植入物和未来脑机接口设备的重要临床应用。智力优点：该 SGER 具有许多功能，对于学习记录神经元电活动非常有用。这将是基于纳米线阵列的设备的首次演示，该设备将允许记录单个神经元中同时位置的电活动，从而实现高空间分辨率。此外，由于纳米线相对于神经元的尺寸较小（通常为几微米数量级），因此对细胞造成的损害最小。这项研究将提供纳米/微加工与生物学的完美结合，为未来使用类似原理的其他新型设备奠定基础。使用纳米线阵列对神经元进行电记录显然是一种新颖的方法，为研究纳米级神经元活动提供了多种可能性。这里提出的纳米线神经元装置将成为研究纳米线和细胞之间生物物理相互作用的模型系统。 纳米线提供了适当生物识别分子功能化的平台，确保细胞固定和更稳定的“细胞附着”电记录。广泛影响：由于纳米线相对于神经元尺寸较小，我们的设备将允许对神经元功能有一个基本的了解，这将影响我们对神经系统疾病和中风背后的神经回路变化的理解。我们的工作更直接的影响将与对细胞与纳米环境相互作用的基本理解有关，这种相互作用不仅与神经元有关，还与癌细胞、干细胞等其他细胞有关。在教育领域，一名研究生将参与这项工作，该项目将导致新实验室设施的开发，特别是与细胞培养和细胞表征有关的实验室设施。