SBIR Phase I: High-Throughput In-Situ Crystallography Screening System

这个小型企业创新研究（SBIR）一期项目旨在开发一种紧凑的高通量原位晶体学筛选系统，该系统可以在培养皿内快速测量晶体的x射线衍射特性，以监测和优化生长条件。这个项目似乎用一个新的系统自动化了这一步骤，该系统使用微聚焦x射线源和带板透镜的组合来直接测量晶体的x射线衍射特性。该项目将完成关键的原位结构筛选步骤，实现晶体学过程的完全自动化，允许在不需要操作员注意的情况下优化生长条件，并确保只选择高质量的晶体进行耗时的衍射数据采集步骤。该项目将对商业/药物发现市场以及进一步阐明蛋白质生物学的基础研究产生相当大的影响。

This Small Business Innovative Research (SBIR) Phase I project aims at developing a compact high-throughput in-situ crystallography screening system that rapidly measures x-ray diffraction properties of crystals while inside the growth dish to monitor and optimize the growth condition. This project seems to automate this step with a novel system using a combination of micro-focus x-ray sources and a zone plate lens to directly measure the crystal's x-ray diffraction property.The project will fulfill the crucial in-situ structure screening step for fully automating the crystallography process by allowing growth conditions to be optimized without the need of operator attention and ensuring that only high-quality crystals are further selected for the time-consuming diffraction data acquisition step. The project will have considerable impact in both commercial/drug discovery markets as we as in basic research for further elucidation of protein biology.