SBIR Phase I: High-Throughput In-Situ Crystallography Screening System

SBIR 第一阶段：高通量原位晶体学筛选系统

• 批准号: 0611112
• 负责人: Steve Wang
• 金额: $ 9.71万
• 依托单位: Xradia
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0611112&HistoricalAwards=false
• 关键词: SBIR; Phase; Throughput; Situ; Crystallography

This Small Business Innovative Research (SBIR) Phase I project aims at developing a compact high-throughput in-situ crystallography screening system that rapidly measures x-ray diffraction properties of crystals while inside the growth dish to monitor and optimize the growth condition. This project seems to automate this step with a novel system using a combination of micro-focus x-ray sources and a zone plate lens to directly measure the crystal's x-ray diffraction property.The project will fulfill the crucial in-situ structure screening step for fully automating the crystallography process by allowing growth conditions to be optimized without the need of operator attention and ensuring that only high-quality crystals are further selected for the time-consuming diffraction data acquisition step. The project will have considerable impact in both commercial/drug discovery markets as we as in basic research for further elucidation of protein biology.

该小型企业创新研究（SBIR）第一阶段项目旨在开发一种紧凑的高通量原位晶体学筛选系统，该系统可在生长皿内快速测量晶体的X射线衍射特性，以监控和优化生长条件。该项目似乎是自动化这一步骤的一个新的系统使用的组合微聚焦x射线源和波带片透镜直接测量晶体的x射线衍射性能。该项目将完成关键的原位结构筛选步骤，使晶体学过程完全自动化，允许生长条件优化，而无需操作员的关注，并确保只有高-为耗时的衍射数据采集步骤进一步选择优质晶体。该项目将对商业/药物发现市场产生相当大的影响，因为我们在基础研究中进一步阐明蛋白质生物学。