Electrical Properties and Sensor Applications of Glass Nanopore Electrodes

玻璃纳米孔电极的电性能和传感器应用

• 批准号: 0616505
• 负责人: Henry White
• 金额: --
• 依托单位: University of Utah
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-10-01 至 2010-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0616505&HistoricalAwards=false
• 关键词: Electrical; Properties; Sensor; Applications; Glass

Professor Henry S. White of the University of Utah is supported by the Analytical and Surface Chemistry Program in the Division of Chemistry to develop methods for fabricating chemically modified glass nanopore electrodes and to investigate their electrical and electrochemical properties. The electrodes will be fabricated by sealing platinum or gold wires in high-resistance glass capillaries, polishing the glass to expose a nanodisk electrode of known radius using electrical feedback circuitry, and etching the metal disk to create a conical shaped pore that is exposed to the analyte solution through a nanometer scale orifice. The objectives of this project are: (1) to optimize the fabrication of electrodes with reproducible 5 nm-radius orifices; (2) to develop alternate-current conductivity methodology to measure the resistance at the pore orifice in response to analyte binding; (3) to design molecular recognition sites and materials for the responsive nanopores; and (4) to evaluate the stimulus-response behavior of the electrodes in specific relevant applications.The long term objective is to develop a self-contained device that could potentially replace the ion-selective electrode, which is employed ubiquitously in chemical and biomedical analysis. The device combines separation and sensing elements for the analysis of chemicals and biochemicals, with sensitivities that could potentially approach the single-molecule level. The project will provide excellent research and professional training opportunities for students in nanotechnology, surface chemistry, biochemistry, electrical measurements, polymer chemistry and computational chemistry.

亨利教授S.犹他州大学的白色由化学系的分析和表面化学项目支持，以开发制造化学改性玻璃纳米孔电极的方法，并研究其电学和电化学性质。 电极将通过将铂或金线密封在高电阻玻璃毛细管中，使用电反馈电路抛光玻璃以暴露已知半径的纳米盘电极，并蚀刻金属盘以产生圆锥形孔来制造，该圆锥形孔通过纳米级孔口暴露于分析物溶液。 本项目的目标是：（1）优化具有可重复的5 nm半径孔的电极的制备;（2）开发交流电导率方法来测量响应于分析物结合的孔孔处的电阻;（3）设计响应性纳米孔的分子识别位点和材料;（4）设计响应性纳米孔的分子识别位点和材料。以及（4）评估电极在特定相关应用中的刺激-响应行为。长期目标是开发一种可能取代离子选择性电极的自包含装置，该装置在化学和生物医学分析中普遍使用。 该设备结合了分离和传感元件，用于分析化学品和生物化学品，其灵敏度可能接近单分子水平。 该项目将为纳米技术，表面化学，生物化学，电学测量，聚合物化学和计算化学的学生提供极好的研究和专业培训机会。