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Collaborative Research: Development of Chirped-Pulse Fourier Transform Microwave Spectrometers for Applications in Biomolecule Electronic Spectroscopy

合作研究：开发用于生物分子电子光谱的啁啾脉冲傅里叶变换微波光谱仪

基本信息

批准号：
0618740
负责人：
David Pratt
金额：
$ 23.16万
依托单位：
University of Pittsburgh
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2006
资助国家：
美国
起止时间：
2006-08-15 至 2009-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=0618740&HistoricalAwards=false
关键词：
Collaborative Research Development Chirped Pulse

项目摘要

With support from the Chemistry Research Instrumentation and Facilities: Instrument Development (CRIF:ID) Program, the Department of Chemistry at the University of Pittsburgh will develop under the direction of David W. Pratt two chirped-pulse Fourier transform microwave (CP-FTMW) spectrometers for applications in biomolecule electronic spectroscopy. This work will be done in collaboration with Brooks H. Pate in the Department of Chemistry at the University of Virginia, Main Campus. The development work will involve studies using laser ablation sources to evaporate involatile molecules, construction of a CP-FTMW 11GHz spectrometer with a coaxial geometry optimized for rotational spectroscopy of biomolecules, and development of a cost-effective CP-FTMW spectrometer with a reduced bandwidth operation of 200MHz. The spectrometers will be compatible with laser sources to undertake UV laser-microwave double resonance spectroscopy. These instruments will be used to determine the structural and dynamical properties of relatively large molecules in the gas phase from their fully resolved pure rotational spectra. Conformationally flexible molecules of biological interest will be particularly investigated. The 11GHz spectrometer will be made available to a network of scientists and students from national laboratories, industry, other universities, including principally undergraduate institutions (PUI). The cost effective 200 MHz spectrometer will allow researchers to fully exploit results from the main spectrometer with experiments performed in their own laboratories. By increasing the accessibility of suchspectrometers, collaborative research with PUI institutions will be enhanced.

在化学研究仪器和设施：仪器开发（CRIF：ID）计划的支持下，匹兹堡大学化学系将在大卫W。Pratt双啁啾脉冲傅里叶变换微波（CP-FTMW）光谱仪，用于生物分子电子光谱学。这项工作将与布鲁克斯H.帕特在弗吉尼亚大学主校区化学系工作。开发工作将涉及使用激光烧蚀源蒸发不挥发性分子的研究，具有优化的同轴几何结构的CP-FTMW 11 GHz光谱仪的构建，用于生物分子的旋转光谱学，以及具有200 MHz带宽操作的成本效益的CP-FTMW光谱仪的开发。光谱仪将与激光源兼容，以进行紫外激光-微波双共振光谱分析。这些仪器将被用来确定结构和动力学性质的相对较大的分子在气相中，从他们的完全解决纯转动光谱。构象灵活的生物学感兴趣的分子将特别调查。11 GHz频谱仪将提供给来自国家实验室，工业，其他大学，主要包括本科院校（PUI）的科学家和学生网络。具有成本效益的200 MHz光谱仪将使研究人员能够充分利用主光谱仪的结果，并在自己的实验室进行实验。通过增加这种光谱仪的可及性，将加强与PUI机构的合作研究。