SGER: A Two-Phase Fluid Model of Prokaryotic Collective Swimming

SGER:原核生物集体游泳的两相流体模型

基本信息

  • 批准号:
    0623870
  • 负责人:
  • 金额:
    $ 4.52万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2006
  • 资助国家:
    美国
  • 起止时间:
    2006-05-01 至 2008-04-30
  • 项目状态:
    已结题

项目摘要

ABSTRACTProposal Number: CTS-0623870 Principal Investigator: Wolgemuth, Charles W.Affiliation: University of Connecticut Health CenterProposal Title: SGER: A two-phase fluid model of prokaryotic collective swimming This proposal suggests the development of a two-phase fluid model to describe thepseudo-turbulent behavior that arises in dense colonies of swimming bacteria. When large populations of bacteria collectively swim, many interesting fluid flows can be generated and these counter-flows produce feedback on the swimming behavior of the bacteria. Therefore,studying the coupling between collective swimming of bacteria and the associated hydrodynamics will lead to a more complete understanding of colony development inlarge populations of swimming micro-organisms, such as can arise during biofilm formation.Recent experiments on dense populations of swimming Bacillus subtilis have revealed a volume fraction-dependent transition from random swimming to transient jet and vortex patterns in the bacteria/fluid mixture. This proposal will develop a model that treats theswimming bacteria as one phase of a multi-phase fluid and the surrounding water as asecond-phase. Intellectual merit: Even modest progress will greatly increase our understanding ofthe multiphase fluid dynamics that arises in bacterial populations, which will haveconsequences for other important areas of bacterial behavior such as biofilm formation.In addition, this project may provide new insights for nano- and micron-scale mixing,which could be applicable for chemical reactor applications. The project is intrinsicallyinter-disciplinary, drawing on ideas from fluid mechanics, applied mathematics, softcondensed matter physics, and biology. Broader impact: The results will be broadly disseminated at interdisciplinaryconferences and in interdisciplinary journals. In addition, the PI will teach methods andresults from this project in an interdisciplinary upper level undergraduate/graduate classthat he has developed entitled. An Introduction to Biophysics, which is cross-listedbetween biomedical engineering, physics, mathematics, and molecular and cellularbiology. This course is taught between the Health Center campus and the main campusof the University of Connecticut.
摘要提案编号:CTS-0623870主要研究者:Wolgemuth,Charles W.附属机构:康涅狄格大学健康中心提案标题:SGER:原核生物集体游动的两相流体模型该提案建议开发一个两相流体模型来描述游动细菌密集菌落中出现的伪湍流行为。当大量细菌集体游动时,可以产生许多有趣的流体流动,这些逆流对细菌的游动行为产生反馈。因此,研究细菌集体游动和相关流体动力学之间的耦合将导致更完整地了解菌落发育inlarge游泳微生物的群体,如可以出现在生物膜formation.Recent实验密集的群体的游泳枯草芽孢杆菌揭示了一个体积分数依赖的过渡从随机游动到瞬态射流和旋涡模式的细菌/流体混合物。该方案将建立一个模型,将游动细菌作为多相流体的一个相,将周围的水作为第二相。智力优点:即使是微小的进展也将大大增加我们对细菌种群中出现的多相流体动力学的理解,这将对细菌行为的其他重要领域产生影响,例如生物膜的形成。此外,该项目可能为纳米和微米尺度的混合提供新的见解,这可能适用于化学反应器的应用。该项目本质上是跨学科的,从流体力学,应用数学,软凝聚态物理学和生物学的想法借鉴。更广泛的影响:研究结果将在跨学科会议和跨学科期刊上广泛传播。此外,PI将在他开发的跨学科高级本科生/研究生课程中教授该项目的方法和结果。 生物物理学导论,它是生物医学工程,物理学,数学,分子和细胞生物学之间的交叉。本课程在康乃狄克大学健康中心校区和主校区之间授课。

项目成果

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Charles Wolgemuth其他文献

Understanding Kink Propagation in Spiroplasma
  • DOI:
    10.1016/j.bpj.2009.12.859
  • 发表时间:
    2010-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Martin Lindén;Charles Wolgemuth;George Oster
  • 通讯作者:
    George Oster
Modeling Actomyosin Contractility in Motile Dendritic Filopodia Resolves Spine Shape in Mature Dendritic Spines
  • DOI:
    10.1016/j.bpj.2011.11.1915
  • 发表时间:
    2012-01-31
  • 期刊:
  • 影响因子:
  • 作者:
    Olena Marchenko;Charles Wolgemuth
  • 通讯作者:
    Charles Wolgemuth
Swimming Microorganisms in Gels
  • DOI:
    10.1016/j.bpj.2009.12.861
  • 发表时间:
    2010-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Henry C. Fu;Vivek Shenoy;Charles Wolgemuth;Thomas R. Powers
  • 通讯作者:
    Thomas R. Powers

Charles Wolgemuth的其他文献

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{{ truncateString('Charles Wolgemuth', 18)}}的其他基金

Biomechanics of the Swimming and Chemotaxis of the Leptospiraceae
钩端螺旋体科游泳和趋化性的生物力学
  • 批准号:
    2309442
  • 财政年份:
    2023
  • 资助金额:
    $ 4.52万
  • 项目类别:
    Standard Grant
Collaborative Research: Mapping protein-membrane interactions from molecules to cell-level dynamics
合作研究:绘制从分子到细胞水平动力学的蛋白质-膜相互作用
  • 批准号:
    2217661
  • 财政年份:
    2022
  • 资助金额:
    $ 4.52万
  • 项目类别:
    Standard Grant
Mechanochemistry of Bacterial Cell Wall Growth
细菌细胞壁生长的机械化学
  • 批准号:
    1361987
  • 财政年份:
    2014
  • 资助金额:
    $ 4.52万
  • 项目类别:
    Standard Grant
The Dynamics of Contracting Gels During Cell Crawling and Blebbing
细胞爬行和起泡期间收缩凝胶的动力学
  • 批准号:
    1338400
  • 财政年份:
    2013
  • 资助金额:
    $ 4.52万
  • 项目类别:
    Continuing Grant
The Dynamics of Contracting Gels During Cell Crawling and Blebbing
细胞爬行和起泡期间收缩凝胶的动力学
  • 批准号:
    0749959
  • 财政年份:
    2009
  • 资助金额:
    $ 4.52万
  • 项目类别:
    Continuing Grant
Research Starter Grant: Cellular Biomechanics of Bacillus subtilis
研究启动资金:枯草芽孢杆菌的细胞生物力学
  • 批准号:
    0327716
  • 财政年份:
    2003
  • 资助金额:
    $ 4.52万
  • 项目类别:
    Standard Grant
Postdoctoral Research Fellowship in Microbial Biology for FY2001
2001财年微生物学博士后研究奖学金
  • 批准号:
    0102095
  • 财政年份:
    2001
  • 资助金额:
    $ 4.52万
  • 项目类别:
    Fellowship Award

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