SGER: Observation of 3D Suspension Transport in Microchannels via High-Speed Confocal Microscopy

SGER：通过高速共焦显微镜观察微通道中的 3D 悬浮液传输

• 批准号: 0630191
• 负责人: James Gilchrist
• 金额: $ 8万
• 依托单位: Lehigh University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0630191&HistoricalAwards=false
• 关键词: SGER; Observation; 3D; Suspension; Transport

ABSTRACTProposal Number: CTS-0630191Principal Investigator: Gilchrist, James F.Affiliation: Lehigh UniversityProposal Title: SGER: Observation of 3D Suspension Transport in Microchannels via High-Speed Confocal Microscopy Intellectual Merit:The exploratory research program will investigate behavior of suspensions in simple and 3Dflows in microchannels. Particle-particle, particle-fluid and particle-field interactions generating particle migration can result in particle self-organization into non-uniform particle distributions. In competition with these processes, chaotic advection, generated by spatial or temporal perturbations to the flow, and diffusion typically result in enhanced dispersion. This study is the first direct investigation of the interplay between flow-induced dispersion and self-organization in microscale systems. Initial exploration of the competition between order and disorder in these systems will be realized via high-speed laser scanning confocal microscopy (CLSM, VisiTech International). These measurements will eventually be used to challenge current models that estimate the concentration profiles resulting from particle migration in 3D chaotic flows.Broader Impacts:Particulate flows in microfluidic geometries are important for cell separations and otheranalytical operations that will likely be the focus of lab-on-a-chip systems of the future. This work will provide both graduate and undergraduate educational opportunities in an area at the convergence of several technologically-critical research areas, including microfluidics and suspension structure. At the graduate level, information disseminated from this research regarding 3D mixing and colloidal flows in microchannels will be incorporated into graduate level Transport Phenomena. For undergraduates, semester/summer research opportunities will provide hands-on experience with microfluidics, suspensions, and high speed CLSM. Information related to this project will be presented at national conferences as well as to local interest groups such as the Lehigh Nanotechnology Network, a consortium of regional companies interested in materials and transport processes at the micro and nanoscale.

摘要Propopales编号：CTS-0630191原理研究者：Gilchrist，James Filiation：Lehigh University Proposalsposal attroposal：SGER：SGER：通过高速共聚焦显微镜智力智力智力：探索性研究计划将在简单和3ddflow中调查微型悬架计划中的3D悬挂运输。颗粒粒子，粒子流体和粒子场相互作用产生粒子迁移会导致粒子自组织成非均匀的粒子分布。在与这些过程的竞争中，由于对流动的空间或时间扰动而产生的混乱对流，扩散通常会导致分散体增强。这项研究是对微观系统中流动诱导的分散体与自组织之间相互作用的首次直接研究。在这些系统中，对秩序与混乱之间的竞争的初步探索将通过高速激光扫描共聚焦显微镜（CLSM，访问国际）实现。这些测量最终将用于挑战当前模型，这些模型估算了3D混沌流中颗粒迁移而产生的浓度曲线。Boader的影响：微流体几何形状中的颗粒流量对于细胞分离和其他分析操作很重要，这些操作可能是实验室的焦点。这项工作将在几个技术关键研究领域（包括微流体和悬架结构）融合的领域提供研究生和本科教育机会。在研究生水平上，这项研究中有关微通道中3D混合和胶体流的信息将纳入研究生水平的运输现象中。对于本科生，学期/夏季的研究机会将提供微流体，悬架和高速CLSM的动手经验。与该项目相关的信息将在国家会议以及当地利益集团（例如Lehigh Nanotechnology Network）上提供，这是对微观和纳米级的材料和运输过程感兴趣的区域公司的财团。