SGER: Observation of 3D Suspension Transport in Microchannels via High-Speed Confocal Microscopy

建议编号：CTS-0630191首席研究员：Gilchrist，James F.隶属关系：利哈伊大学建议标题：SGER：通过高速共焦显微镜观察微通道中的3D悬浮传输智力优点：探索性研究计划将调查微通道中简单和三维流动中的悬浮行为。产生粒子迁移的粒子-粒子、粒子-流体和粒子-场相互作用会导致粒子自组织成不均匀的粒子分布。在与这些过程的竞争中，由流动的空间或时间扰动产生的混沌平流和扩散通常导致增强的弥散。这项研究是第一次直接研究微观系统中流动诱导的弥散和自组织之间的相互作用。通过高速激光扫描共聚焦显微镜(CLSM，VisiTech International)，将初步探索这些系统中有序和无序之间的竞争。这些测量最终将被用来挑战目前的模型，这些模型估计了3D混沌流动中颗粒迁移产生的浓度分布。更广泛的影响：微流控几何中的颗粒流对于细胞分离和其他分析操作非常重要，这些操作可能会成为未来芯片实验室系统的重点。这项工作将在包括微流体和悬浮结构在内的几个关键技术研究领域的汇合处为研究生和本科生提供教育机会。在研究生阶段，这项研究传播的有关微通道中三维混合和胶体流动的信息将被纳入研究生水平的输运现象。对于本科生来说，学期/暑期的研究机会将提供微流体、悬浮液和高速CLSM的实践经验。与该项目有关的信息将在国家会议上以及地方利益集团，如利哈伊纳米技术网络，这是一个对微米和纳米尺度的材料和运输工艺感兴趣的区域公司联盟。

ABSTRACTProposal Number: CTS-0630191Principal Investigator: Gilchrist, James F.Affiliation: Lehigh UniversityProposal Title: SGER: Observation of 3D Suspension Transport in Microchannels via High-Speed Confocal Microscopy Intellectual Merit:The exploratory research program will investigate behavior of suspensions in simple and 3Dflows in microchannels. Particle-particle, particle-fluid and particle-field interactions generating particle migration can result in particle self-organization into non-uniform particle distributions. In competition with these processes, chaotic advection, generated by spatial or temporal perturbations to the flow, and diffusion typically result in enhanced dispersion. This study is the first direct investigation of the interplay between flow-induced dispersion and self-organization in microscale systems. Initial exploration of the competition between order and disorder in these systems will be realized via high-speed laser scanning confocal microscopy (CLSM, VisiTech International). These measurements will eventually be used to challenge current models that estimate the concentration profiles resulting from particle migration in 3D chaotic flows.Broader Impacts:Particulate flows in microfluidic geometries are important for cell separations and otheranalytical operations that will likely be the focus of lab-on-a-chip systems of the future. This work will provide both graduate and undergraduate educational opportunities in an area at the convergence of several technologically-critical research areas, including microfluidics and suspension structure. At the graduate level, information disseminated from this research regarding 3D mixing and colloidal flows in microchannels will be incorporated into graduate level Transport Phenomena. For undergraduates, semester/summer research opportunities will provide hands-on experience with microfluidics, suspensions, and high speed CLSM. Information related to this project will be presented at national conferences as well as to local interest groups such as the Lehigh Nanotechnology Network, a consortium of regional companies interested in materials and transport processes at the micro and nanoscale.