SGER: Observation of 3D Suspension Transport in Microchannels via High-Speed Confocal Microscopy

摘要：项目编号：cts -0630191项目负责人：Gilchrist， James f .归属：美国里海大学项目名称：SGER：用高速共聚焦显微镜观察微通道中三维悬浮液的运移知识价值：探索性研究项目将研究微通道中简单和三维流动中的悬浮液的行为。产生粒子迁移的粒子-粒子、粒子-流体和粒子-场相互作用可以导致粒子自组织成不均匀的粒子分布。在与这些过程的竞争中，混沌平流（由流动的空间或时间扰动产生）和扩散通常会导致弥散增强。这项研究首次直接研究了微尺度系统中流动诱导的分散和自组织之间的相互作用。这些系统中有序和无序竞争的初步探索将通过高速激光扫描共聚焦显微镜（CLSM, VisiTech International）实现。这些测量结果最终将用于挑战目前的模型，这些模型估计了三维混沌流中颗粒迁移引起的浓度分布。更广泛的影响：微流体几何形状中的颗粒流动对于细胞分离和其他分析操作很重要，这可能是未来芯片实验室系统的重点。这项工作将在几个技术关键研究领域的融合领域提供研究生和本科生教育机会，包括微流体和悬浮结构。在研究生阶段，从这项研究中传播的关于微通道中三维混合和胶体流动的信息将被纳入研究生水平的传输现象。对于本科生，学期/夏季的研究机会将提供微流体，悬浮液和高速CLSM的实践经验。与这个项目有关的信息将在国家会议上以及当地的兴趣团体上展示，比如利哈伊纳米技术网络，这是一个由对微观和纳米尺度的材料和运输过程感兴趣的地区公司组成的联盟。

ABSTRACTProposal Number: CTS-0630191Principal Investigator: Gilchrist, James F.Affiliation: Lehigh UniversityProposal Title: SGER: Observation of 3D Suspension Transport in Microchannels via High-Speed Confocal Microscopy Intellectual Merit:The exploratory research program will investigate behavior of suspensions in simple and 3Dflows in microchannels. Particle-particle, particle-fluid and particle-field interactions generating particle migration can result in particle self-organization into non-uniform particle distributions. In competition with these processes, chaotic advection, generated by spatial or temporal perturbations to the flow, and diffusion typically result in enhanced dispersion. This study is the first direct investigation of the interplay between flow-induced dispersion and self-organization in microscale systems. Initial exploration of the competition between order and disorder in these systems will be realized via high-speed laser scanning confocal microscopy (CLSM, VisiTech International). These measurements will eventually be used to challenge current models that estimate the concentration profiles resulting from particle migration in 3D chaotic flows.Broader Impacts:Particulate flows in microfluidic geometries are important for cell separations and otheranalytical operations that will likely be the focus of lab-on-a-chip systems of the future. This work will provide both graduate and undergraduate educational opportunities in an area at the convergence of several technologically-critical research areas, including microfluidics and suspension structure. At the graduate level, information disseminated from this research regarding 3D mixing and colloidal flows in microchannels will be incorporated into graduate level Transport Phenomena. For undergraduates, semester/summer research opportunities will provide hands-on experience with microfluidics, suspensions, and high speed CLSM. Information related to this project will be presented at national conferences as well as to local interest groups such as the Lehigh Nanotechnology Network, a consortium of regional companies interested in materials and transport processes at the micro and nanoscale.