SGER: Observation of 3D Suspension Transport in Microchannels via High-Speed Confocal Microscopy

摘要提案编号：CTS-0630191首席研究员：Gilchrist，James F.附属机构：Lehigh University提案标题：SGER：通过高速共聚焦显微镜观察微通道中的3D悬浮液传输知识点：探索性研究计划将研究微通道中简单和3D流动中悬浮液的行为。粒子-粒子、粒子-流体和粒子-场相互作用产生粒子迁移，可导致粒子自组织成非均匀的粒子分布。在与这些过程的竞争中，由空间或时间扰动产生的混沌平流和扩散通常会导致分散增强。这项研究是第一次直接调查之间的相互作用流动诱导的分散和自组织在微尺度系统。这些系统中有序和无序之间的竞争的初步探索将通过高速激光扫描共聚焦显微镜（CLSM，VisiTech International）实现。这些测量结果最终将被用来挑战目前的模型，估计浓度分布造成的粒子迁移在3D混沌flow.Broader影响：微流体几何形状的颗粒流是重要的细胞分离和其他分析操作，这将可能是未来的重点实验室芯片系统。这项工作将提供研究生和本科生教育机会，在一个地区的几个技术关键的研究领域，包括微流体和悬浮结构的融合。在研究生阶段，从这项研究中传播的关于微通道中的3D混合和胶体流的信息将被纳入研究生阶段的传输现象。对于本科生，学期/夏季研究机会将提供微流体，悬浮液和高速CLSM的实践经验。与该项目有关的信息将在国家会议上以及向当地利益集团，如Lehigh纳米技术网络，一个对微米和纳米级材料和运输过程感兴趣的区域公司联盟介绍。

ABSTRACTProposal Number: CTS-0630191Principal Investigator: Gilchrist, James F.Affiliation: Lehigh UniversityProposal Title: SGER: Observation of 3D Suspension Transport in Microchannels via High-Speed Confocal Microscopy Intellectual Merit:The exploratory research program will investigate behavior of suspensions in simple and 3Dflows in microchannels. Particle-particle, particle-fluid and particle-field interactions generating particle migration can result in particle self-organization into non-uniform particle distributions. In competition with these processes, chaotic advection, generated by spatial or temporal perturbations to the flow, and diffusion typically result in enhanced dispersion. This study is the first direct investigation of the interplay between flow-induced dispersion and self-organization in microscale systems. Initial exploration of the competition between order and disorder in these systems will be realized via high-speed laser scanning confocal microscopy (CLSM, VisiTech International). These measurements will eventually be used to challenge current models that estimate the concentration profiles resulting from particle migration in 3D chaotic flows.Broader Impacts:Particulate flows in microfluidic geometries are important for cell separations and otheranalytical operations that will likely be the focus of lab-on-a-chip systems of the future. This work will provide both graduate and undergraduate educational opportunities in an area at the convergence of several technologically-critical research areas, including microfluidics and suspension structure. At the graduate level, information disseminated from this research regarding 3D mixing and colloidal flows in microchannels will be incorporated into graduate level Transport Phenomena. For undergraduates, semester/summer research opportunities will provide hands-on experience with microfluidics, suspensions, and high speed CLSM. Information related to this project will be presented at national conferences as well as to local interest groups such as the Lehigh Nanotechnology Network, a consortium of regional companies interested in materials and transport processes at the micro and nanoscale.