Photolabile reporters of molecular recognition: caging, tagging and photoamplification

分子识别的不稳定性报告基因：笼养、标记和光放大

• 批准号: 0640838
• 负责人: Andrei Kutateladze
• 金额: --
• 依托单位: University of Denver
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-15 至 2011-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0640838&HistoricalAwards=false
• 关键词: Photolabile; reporters; molecular; recognition; caging

With this award, the Organic and Macromolecular Chemistry Program supports the work of Professor Andrei G. Kutateladze of the University of Denver. This research will involve the design and development of a new generation of photolabile systems that are capable of efficient photoinduced fragmentation. They will be reacted using molecular recognition events, and will contain groups which will allow incorporation of these systems into certain polymer assemblies. Utilizing these systems, several fundamentally novel bioanalytical methodologies will be developed. Further, a variety of studies will be undertaken to obtain a thorough understanding of the molecular mechanism of the photoinduced fragmentations. Broader Impacts. A major broader impact of this research will be in the fundamental understanding of the principles governing these photoreactions since the findings will have broader implications in several fields, including high throughput screening, bio-analytical techniques and biophotonics. The research will provide broad and extensive training for the students (including female and minority students) since it involves an extensive variety of techniques. It will help develop in these students a comprehensive set of experimental and theoretical skills needed in order to carry out productive work in an academic or industrial setting.

通过这个奖项，有机化学和高分子化学项目支持丹佛大学安德烈·G·库特拉泽教授的工作。这项研究将涉及设计和开发能够有效光致碎裂的新一代耐光系统。它们将使用分子识别事件进行反应，并将包含允许将这些系统合并到某些聚合物组件中的基团。利用这些系统，将开发出几种全新的生物分析方法。此外，还将进行各种研究，以彻底了解光诱导碎裂的分子机制。更广泛的影响。这项研究的一个重大的更广泛的影响将是对这些光反应原理的基本理解，因为这些发现将在几个领域产生更广泛的影响，包括高通量筛选、生物分析技术和生物光子学。这项研究将为学生(包括女学生和少数民族学生)提供广泛和广泛的培训，因为它涉及广泛的各种技术。它将帮助这些学生培养在学术或工业环境中开展生产性工作所需的一套全面的实验和理论技能。