Photolabile reporters of molecular recognition: caging, tagging and photoamplification

通过这个奖项，有机和大分子化学项目支持丹佛大学安德烈·g·库塔泰拉泽教授的工作。这项研究将涉及设计和开发新一代能够有效光诱导破碎的光致性系统。它们将使用分子识别事件进行反应，并且将包含允许将这些系统并入某些聚合物组件的基团。利用这些系统，几个基本新颖的生物分析方法将被开发出来。此外，将进行各种研究，以获得对光诱导碎片的分子机制的透彻理解。更广泛的影响。这项研究的主要影响将是对这些光反应原理的基本理解，因为这些发现将在几个领域产生更广泛的影响，包括高通量筛选、生物分析技术和生物光子学。这项研究将为学生（包括女性和少数民族学生）提供广泛而广泛的培训，因为它涉及各种各样的技术。它将帮助这些学生发展一套全面的实验和理论技能，以便在学术或工业环境中开展生产性工作。

With this award, the Organic and Macromolecular Chemistry Program supports the work of Professor Andrei G. Kutateladze of the University of Denver. This research will involve the design and development of a new generation of photolabile systems that are capable of efficient photoinduced fragmentation. They will be reacted using molecular recognition events, and will contain groups which will allow incorporation of these systems into certain polymer assemblies. Utilizing these systems, several fundamentally novel bioanalytical methodologies will be developed. Further, a variety of studies will be undertaken to obtain a thorough understanding of the molecular mechanism of the photoinduced fragmentations. Broader Impacts. A major broader impact of this research will be in the fundamental understanding of the principles governing these photoreactions since the findings will have broader implications in several fields, including high throughput screening, bio-analytical techniques and biophotonics. The research will provide broad and extensive training for the students (including female and minority students) since it involves an extensive variety of techniques. It will help develop in these students a comprehensive set of experimental and theoretical skills needed in order to carry out productive work in an academic or industrial setting.