Modular Photoassisted Diversity-Oriented Synthesis

模块化光辅助多样性导向合成

• 批准号: 1057800
• 负责人: Andrei Kutateladze
• 金额: $ 37.5万
• 依托单位: University of Denver
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2014-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1057800&HistoricalAwards=false
• 关键词: Modular; Photoassisted; Diversity; Oriented; Synthesis

The Chemical Structure, Dynamics and Mechanisms Program in the Chemistry Division at the National Science Foundation supports Professor Andre Kutateladze of the University of Denver, for the development of new one-pot photo-protolytic oxametathesis reactions. The goal of this work is to use this type of photochemical reaction for what is known as "diversity-oriented synthesis," or DOS. The versatility and generality of this methodology will allow Dr. Kutateladze's group to access heretofore inaccessible carbon skeletons, giving rise to new organic molecules that can be rapidly screened for therapeutic activity. The work will also involve an innovative new method for rapid structure determination by NMR spectroscopy.Broader impacts of the research include the multidisciplinary training opportunities for students, from organic synthesis to photochemistry and photophysics. Potential applications for the synthesized molecules in biology and medicine include new drug discovery at more rapid pace. Undergraduate participation in this research will be year-round, and Dr. Kutateladze is making a significant effort to attract students from underrepresented groups to his laboratory.

国家科学基金会化学部的化学结构，动力学和机制计划支持丹佛大学的Andre Kutateladze教授开发新的一锅光质子化oxametathesis反应。这项工作的目标是使用这种类型的光化学反应进行所谓的“多样性导向合成”（DOS）。这种方法的多功能性和通用性将使Kutateladze博士的研究小组能够获得迄今为止无法获得的碳骨架，从而产生新的有机分子，这些分子可以快速筛选出治疗活性。这项研究的更广泛影响包括为学生提供多学科培训机会，从有机合成到光化学和光物理学。合成分子在生物学和医学上的潜在应用包括更快地发现新药。本科生参与这项研究将是全年的，Kutateladze博士正在做出重大努力，以吸引学生从代表性不足的群体到他的实验室。